ArticleBehavior therapy2017
Implementing Clinical Research Using Factorial Designs: A Primer.
Article in Behavior therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01814072 (Opt-IN), which is not on this map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Opt-IN: Optimization of Remotely Delivered Intensive Lifestyle Treatment for Obesity
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Community Health Worker Training Curricula and Intervention Outcomes in African American and Latinx Communities: A Systematic Review.Health education & behavior : the official publication of the Society for Public Health Education · 2021Pooled it
- Pooled it
- A virtual pilot optimization trial for African American/Black and Latino persons with non-suppressed HIV viral load grounded in motivational interviewing and behavioral economics.Frontiers in public health · 2023Trial
- Six-Month Outcomes from the NEXit Junior Trial of a Text Messaging Smoking Cessation Intervention for High School Students: Randomized Controlled Trial With Bayesian Analysis.JMIR mHealth and uHealth · 2021Trial
- Individually Tailored Internet-Based Cognitive-Behavioral Therapy for Daily Functioning in Patients with Parkinson's Disease: A Randomized Controlled Trial.Journal of Parkinson's disease · 2020Trial
- A Randomized Controlled Trial of an Optimized Smoking Treatment Delivered in Primary Care.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018Trial
- Rapid Innovation of Precision Psychiatry Interventions Using Dynamical Systems Modeling and Ecological Quasi-Experiments: Protocol for a Proof-of-Concept Study on Eating Disorders.JMIR research protocols · 2026Article
- Two-level non-regular fractional factorial designs for public health studies.BMC medical research methodology · 2026Article
- Alzheimer Combination Therapies: Overview and Scenarios.The journal of prevention of Alzheimer's disease · 2025Review
- A Bayesian Multi-Factorial Design and Analysis for Estimating Combined Effects of Multiple Interventions in a Pragmatic Clinical Trial to Improve Dementia Care.Statistics in medicine · 2025Article
- Nonparametric analysis of quality-of-life measures for randomized clustered design: the R package npclust.BMC medical research methodology · 2025Article
- Optimizing Intervention Components of a Preventive Stress Management mHealth Intervention for Health Care Workers: Experimental Factorial Study.JMIR formative research · 2025Article
- What is the best nutritional strategy for moderate to late preterm infants?Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Guidance for protocol content and reporting of factorial randomised trials: explanation and elaboration of the CONSORT 2010 and SPIRIT 2013 extensions.BMJ (Clinical research ed.) · 2025Article
- Comparison of the Effects of Music Therapy and Aromatherapy on Physiological Indices in Surgical Patients: A Randomized Parallel-Group Trial.Scientifica · 2025Article
- Designing and developing a prescription digital therapeutic for at-home heart rate variability biofeedback to support and enhance patient outcomes in post-traumatic stress disorder treatment.Frontiers in digital health · 2025Article
- Article
- When should factorial designs be used for late-phase randomised controlled trials?Clinical trials (London, England) · 2024Review
- Article
- PATHway: Intervention optimization of a prevention program for adolescents at-risk for depression in the primary care setting.Contemporary clinical trials · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Factorial experiments have rarely been used in the development or evaluation of clinical interventions. However, factorial designs offer advantages over randomized controlled trial designs, the latter being much more frequently used in such research. Factorial designs are highly efficient (permitting evaluation of multiple intervention components with good statistical power) and present the opportunity to detect interactions amongst intervention components. Such advantages have led methodologists to advocate for the greater use of factorial designs in research on clinical interventions (Collins, Dziak, & Li, 2009). However, researchers considering the use of such designs in clinical research face a series of choices that have consequential implications for the interpretability and value of the experimental results. These choices include: whether to use a factorial design, selection of the number and type of factors to include, how to address the compatibility of the different factors included, whether and how to avoid confounds between the type and number of interventions a participant receives, and how to interpret interactions. The use of factorial designs in clinical intervention research poses choices that differ from those typically considered in randomized clinical trial designs. However, the great information yield of the former encourages clinical researchers' increased and careful execution of such designs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.