ArticleBehavior therapy2017
Advancing Personalized Medicine: Application of a Novel Statistical Method to Identify Treatment Moderators in the Coordinated Anxiety Learning and Management Study.
Article in Behavior therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychotherapy or medication for depression? Using individual symptom meta-analyses to derive a Symptom-Oriented Therapy (SOrT) metric for a personalised psychiatry.BMC medicine · 2020Pooled it
- Identifying subgroups with differential response to CBASP versus Escitalopram during the first eight weeks of treatment in outpatients with persistent depressive disorder.European archives of psychiatry and clinical neuroscience · 2024Trial
- Trial
- Precision medicine for long-term depression outcomes using the Personalized Advantage Index approach: cognitive therapy or interpersonal psychotherapy?Psychological medicine · 2021Trial
- Getting to precision psychopharmacology: Combining clinical and genetic information to predict fat gain from aripiprazole.Journal of psychiatric research · 2019Trial
- Effects of Choice Set Sizes and Moderations of Anxiety and State Emotions on Mental Health Self-Care Uptake, Engagement, and User Experience: Experimental Study.JMIR human factors · 2025Article
- Predictive approaches to heterogeneous treatment effects: a scoping review.BMC medical research methodology · 2020Article
- The Predictive Approaches to Treatment effect Heterogeneity (PATH) Statement: Explanation and Elaboration.Annals of internal medicine · 2020Article
- Cognitive and Interpersonal Vulnerabilities to Adolescent Depression: Classification of Risk Profiles for a Personalized Prevention Approach.Journal of abnormal child psychology · 2018Article
- [Anxiety disorders: which psychotherapy for whom?]Der Nervenarzt · 2018Review
- Building on the past 50 years, not starting over: A balanced interpretation of meta-analyses, reviews, and commentaries on treatments for suicide and self-injury.General hospital psychiatryArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
There has been increasing recognition of the value of personalized medicine where the most effective treatment is selected based on individual characteristics. This study used a new method to identify a composite moderator of response to evidence-based anxiety treatment (CALM) compared to Usual Care. Eight hundred seventy-six patients diagnosed with one or multiple anxiety disorders were assigned to CALM or Usual Care. Using the method proposed by Kraemer (2013), 35 possible moderators were examined for individual effect sizes then entered into a forward-stepwise regression model predicting differential treatment response. K-fold cross validation was used to identify the number of variables to include in the final moderator. Ten variables were selected for a final composite moderator. The composite moderator effect size (r = .20) was twice as large as the strongest individual moderator effect size (r = .10). Although on average patients benefitted more from CALM, 19% of patients had equal or greater treatment response in Usual Care. The effect size for the CALM intervention increased from d = .34 to d = .54 when accounting for the moderator. Findings support the utility of composite moderators. Results were used to develop a program that allows mental health professionals to prescribe treatment for anxiety based on baseline characteristics (http://anxiety.psych.ucla.edu/treatmatch.html).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.