Evidence map›Paper›PMID 28577439›Full record

ArticleTranslational oncology2017

Targeted α-Particle Radiation Therapy of HER1-Positive Disseminated Intraperitoneal Disease: An Investigation of the Human Anti-EGFR Monoclonal Antibody, Panitumumab.

Diane E Milenic, Kwamena E Baidoo, Young-Seung Kim, Rachel Barkley, Martin W Brechbiel

Open access · goldAbstract read
In one paragraph

Article in Translational oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. EJNMMI radiopharmacy and chemistry · 2025
    Review
  3. Article
  4. Targeted Radium Alpha Therapy in the Era of Nanomedicine: In Vivo Results.International journal of molecular sciences · 2024
    Review
  5. CD46 targetedJournal of experimental & clinical cancer research : CR · 2023
    Article
  6. Review
  7. National Cancer Institute support for targeted alpha-emitter therapy.European journal of nuclear medicine and molecular imaging · 2021
    Review
  8. A Novel Single-Step-LabeledMaterials (Basel, Switzerland) · 2021
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Radium and other alpha emitters in prostate cancer.Translational andrology and urology · 2018
    Review
  14. Exploration of a F(ab')Cancer biotherapy & radiopharmaceuticals · 2018
    Article
  15. Therapeutic Effect of α-EmittingTranslational oncology · 2018
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Diane E MilenicRadioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address: milenicd@mail.nih.gov.
Kwamena E BaidooRadioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Young-Seung KimRadioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Rachel BarkleyRadioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Martin W BrechbielRadioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
National Cancer Institute · USNational Institutes of Health · US

Funding

Metal Chelate Conjugated Monoclonal Antibodies for Tumor Diagnosis and TherapyZIASC006353 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI BRECHBIEL, MARTIN W · 2009 to 2017
$9.4M
6 · The paper itself

Abstract

Identifying molecular targets and an appropriate targeting vehicle, i.e., monoclonal antibodies (mAb) and their various forms, for radioimmunotherapy (RIT) remains an active area of research. Panitumumab, a fully human and less immunogenic mAb that binds to the epidermal growth factor receptor (Erb1; HER1), was evaluated for targeted α-particle radiation therapy using

Identifiers

PMID28577439
PMCPMC5458064
OpenAlexW2621153471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.