ArticlePsychiatry research. Neuroimaging2017
Reduced fronto-amygdalar connectivity in adolescence is associated with increased depression symptoms over time.
Article in Psychiatry research. Neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies.Developmental cognitive neuroscience · 2019Pooled it
- Changes in resting-state functional connectivity linked to affective symptoms: insights from a population-based study of adolescents and young adults.Translational psychiatry · 2026Article
- Group Sparse Representation Enhances Brain Network Classification of Major Depressive Disorder in Two Chinese Cohorts.Alpha psychiatry · 2026Article
- Exercise-induced anandamide-CB1R signaling and prefrontal-amygdala stress circuits in adolescent depression: a critical hypothesis-driven narrative review.Frontiers in psychiatry · 2026Review
- The different impacts of functional network centrality and connectivity on the complexity of brain signals in healthy control and first-episode drug-naïve patients with major depressive disorder.Brain imaging and behavior · 2025Article
- Examining anterior prefrontal cortex resting-state functional connectivity patterns associated with depressive symptoms in chronic moderate-to-severe traumatic brain injury.Frontiers in neurology · 2025Article
- Practical, Economic, and Policy Implications of the Leve et al. Paper.Prevention science : the official journal of the Society for Prevention Research · 2024Article
- Review of the Brain's Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM).Biomimetics (Basel, Switzerland) · 2024Review
- Corticolimbic connectivity mediates the relationship between pubertal timing and mental health problems.Psychological medicine · 2023Article
- Screen Media Use Affects Subcortical Structures, Resting-State Functional Connectivity, and Mental Health Problems in Early Adolescence.Brain sciences · 2023Article
- Organization of the social cognition network predicts future depression and interpersonal impairment: a prospective family-based study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Sex-specific patterns of white matter microstructure are associated with emerging depression during adolescence.Psychiatry research. Neuroimaging · 2021Article
- Repetitive Transcranial Magnetic Stimulation for Adolescent Major Depressive Disorder: A Focus on Neurodevelopment.Frontiers in psychiatry · 2021Review
- Research Review: Brain network connectivity and the heterogeneity of depression in adolescence - a precision mental health perspective.Journal of child psychology and psychiatry, and allied disciplines · 2020Review
- Sex Differences in Internalizing Symptoms and Amygdala Functional Connectivity in Neurotypical Youth.Developmental cognitive neuroscience · 2020Article
- MRI Insights Into Adolescent Neurocircuitry-A Vision for the Future.Frontiers in human neuroscience · 2020Article
- Article
- Neural Markers of Resilience in Adolescent Females at Familial Risk for Major Depressive Disorder.JAMA psychiatry · 2018Article
- Convergent neurobiological predictors of emergent psychopathology during adolescence.Birth defects research · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Depression is common among adolescents, affecting greater than 12% of youth in a given year. Studies have shown aberrant amygdala connectivity in depressed adolescents, compared with controls; however, no studies have examined whether these abnormalities precede and heighten risk for depressive symptom expression. This study used resting state functional connectivity (RSFC) magnetic resonance imaging to examine neurobiological markers of escalating depression symptoms in adolescents (ages 12-16 years; free from psychopathology at baseline). Of a large sample of adolescents, 18 showed ≥ 1 S.D. increase in depression scale t-scores over time ("escalators"; time to escalation ranging from 6 to 54 months in follow up) and were matched and compared to 19 youth showing stable CDI scores over time ("controls"). Whole-brain analyses on baseline RSFC data using an amygdala seed region-of-interest (ROI) showed that controls had greater RSFC, relative to escalators, between the right amygdala and left inferior frontal and supramarginal gyrus and right mid-cingulate cortex. Additionally, relative to escalators, control youth had less RSFC between the left amygdala and cerebellum. Findings suggest a possible neurobiological marker of increasing depressive symptoms during adolescence, characterized in part by reduced fronto-limbic connectivity, suggesting a premorbid deficiency in top-down emotional regulation.
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