ArticleBMC research notes2017
Prevalence of methicillin resistant Staphylococcus aureus in Lumbini Medical College and Teaching Hospital, Palpa, Western Nepal.
Article in BMC research notes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global prevalence of macrolide-resistantFrontiers in microbiology · 2025Pooled it
- Prevalence, Antimicrobial Resistance Profile, and Multidrug Resistance of Methicillin-ResistantHealth science reports · 2026Article
- Methicillin-resistant Staphylococcus aureus colonization and associated factors in clinical isolates among patients attending a tertiary medical centre in Nigeria.BMC infectious diseases · 2025Article
- Article
- Current Antibiotic Resistance Profile of ESKAPE Pathogens in a Nepalese Hospital: A Cross-Sectional Study.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Article
- Nasal Carriage of Methicillin-ResistantInterdisciplinary perspectives on infectious diseases · 2025Article
- Phenotypic and genotypic characterization of commensal staphylococci isolated from young volunteers in Alexandria, Egypt.Scientific reports · 2024Article
- Potential Surviving Effect ofAntibiotics (Basel, Switzerland) · 2024Article
- Epidemiology ofAntibiotics (Basel, Switzerland) · 2023Review
- Prevalence, antimicrobial susceptibility pattern and multidrug resistance of methicillin-resistantBMJ open · 2023Observational
- Article
- Antibiotics Prescription, Dispensing Practices and Antibiotic Resistance Pattern in Common Pathogens in Nepal: A Narrative Review.Microbiology insights · 2023Review
- Inducible Clindamycin Resistant Staphylococcus aureus among Patients Attending Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2021Article
- Antibiotic Susceptibility, Biofilm Production, and Detection ofDiseases (Basel, Switzerland) · 2021Article
- Methicillin-resistant Staphylococcus aureus in Nepal.JNMA; journal of the Nepal Medical Association · 2021Article
- Prevalence of Methicillin Resistant Staphylococcus aureus Nasal Colonizers among Basic Science MBBS and BDS Students of Kathmandu Medical College.JNMA; journal of the Nepal Medical Association · 2021Article
- Methicillin-ResistantInfectious diseases · 2021Article
- Molecular Confirmation of Vancomycin-ResistantInternational journal of microbiology · 2021Article
- Methicillin-resistantPathogens and global health · 2020Article
- Prevalence of methicillin-resistantInfection prevention in practice · 2020Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultidrug resistant Staphylococcus aureus is common in both tertiary and primary health care settings. Emergence of methicillin resistance in S. aureus (MRSA) along with macrolide, lincosamide, streptogramin B (MLSB) has made treatment of Staphylococcal infection more challenging. The main objective of this study was to detect MRSA, MLSB (inducible; MLSBi and constitutive; MLSBc) resistant S. aureus using phenotypic methods and to determine their antibiogram.
methodsVarious samples were collected from 1981 patients who attended Lumbini Medical College and Teaching Hospital (LMCTH) during the period of 6 months from September 2015 to February 2016. Out of a total of 1981 samples, 133 S. aureus were isolated. Cefoxitin was used to detect MRSA by the disk diffusion test. Inducible clindamycin resistance (MLSBi) was detected by the D-zone test. The antibiotic profile of all isolates was tested by a modified Kirby Bauer disk diffusion method.
resultsAmong 133 S. aureus, there were 58 (43.6%) MRSA, 34 (25.6%) MLSBi and 30 (22.6%) MLSBc. Of a total of 64 MLSB, a significant proportion (62.5%) was MRSA (p < 0.001). Among 11 different antibiotics that were tested for S. aureus, MRSA showed significant resistance to 9 (p < 0.05) with the exception of vancomycin and linezolid. All the isolates were 100% sensitive to linezolid. MLSBi organisms were 100% sensitive to vancomycin and linezolid. Both MLSBi and MLSBc showed a higher degree of resistance to multiple antibiotics (p < 0.05).
conclusionsIsolation of MRSA, MLSBi and MLSBc were remarkably high. Routine use of simple and cost effective methods such as the disk diffusion test by cefoxitin for MRSA and the D-zone test for MLSBi organisms can easily identify these isolates. Antibiotic resistance profiles from this study can optimize the treatment of multi-drug resistant S. aureus.
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