Evidence map›Paper›PMID 28577154›Full record

ArticleCancer causes & control : CCC2017

Association of endometrial hyperplasia and cancer with a history of gestational diabetes.

Paige D Wartko, Tiffany L Beck, Susan D Reed, Beth A Mueller, Stephen E Hawes

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Paige D WartkoDepartment of Epidemiology, University of Washington School of Public Health, 1959 NE Pacific Street, Health Sciences Building, F-262, Box 357660, Seattle, WA, 98195-7236, USA. pwartko@uw.edu.
Tiffany L BeckDepartment of Epidemiology, University of Washington School of Public Health, 1959 NE Pacific Street, Health Sciences Building, F-262, Box 357660, Seattle, WA, 98195-7236, USA.
Susan D ReedDepartment of Epidemiology, University of Washington School of Public Health, 1959 NE Pacific Street, Health Sciences Building, F-262, Box 357660, Seattle, WA, 98195-7236, USA.
Beth A MuellerDepartment of Epidemiology, University of Washington School of Public Health, 1959 NE Pacific Street, Health Sciences Building, F-262, Box 357660, Seattle, WA, 98195-7236, USA.
Stephen E HawesDepartment of Epidemiology, University of Washington School of Public Health, 1959 NE Pacific Street, Health Sciences Building, F-262, Box 357660, Seattle, WA, 98195-7236, USA.
University of Washington · US

Funding

University of Washington Reproductive, Perinatal and Pediatric Epidemiology T32HD052462 · NICHD · UNIVERSITY OF WASHINGTON · PI HOLT, VICTORIA L · 2006 to 2017
$2.7M
NICHD NIH HHS T32 HD052462
6 · The paper itself

Abstract

purposeExcess circulating insulin may contribute to endometrial cancer (EC) development; studies suggest increased risk of EC associated with type 2 diabetes. We investigated whether gestational diabetes is associated with increased risk of EC and its precursor, endometrial hyperplasia (EH).

methodsWe conducted a population-based, case-control study of women in Washington State. Cases were women with a hospital discharge record indicating the presence of EH/EC who could be linked to a prior delivery hospitalization or birth record from 1987 to 2013 (n = 593). Controls were randomly selected from remaining deliveries, frequency matched 10:1 on delivery year and maternal age at delivery (n = 5,743). Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).

resultsAfter adjustment for race/ethnicity, maternal age at delivery, and delivery year, EH/EC was associated with a history of gestational diabetes (OR 1.73, 95% CI 1.27-2.35). This association was present for both EH and EC (OR 1.61, 95% CI 1.00-2.60 and OR 1.80, 95% CI 1.22-2.65, respectively). After adjustment for prepregnancy body mass index, the OR for EH/EC was attenuated and became statistically non-significant (OR 1.22, 95% CI 0.87-1.72), except in women <50 years old at the time of case ascertainment (OR 1.49, 95% CI 1.00-2.20). Associations were slightly stronger for EC than EH.

conclusionsWe observed an association between EH/EC and a history of gestational diabetes specific to younger women. Future studies focusing on the relationships between gestational diabetes, obesity, and EC, including age at diagnosis, are warranted.

Indexed as

AdultCase-Control StudiesDiabetes, GestationalEndometrial HyperplasiaEndometrial NeoplasmsFemaleHumansLogistic ModelsMiddle AgedOdds RatioPregnancyWashingtonBody mass indexCase–control studyEndometrial cancerEndometrial hyperplasiaGestational diabetes mellitusPregnancy

Identifiers

PMID28577154
PMCPMC8487256
OpenAlexW2621051757

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.