Evidence map›Paper›PMID 28577131›Full record

ReviewJournal of digital imaging2017

Deep Learning for Brain MRI Segmentation: State of the Art and Future Directions.

Zeynettin Akkus, Alfiia Galimzianova, Assaf Hoogi, Daniel L Rubin, Bradley J Erickson

Abstract readReview
In one paragraph

Review in Journal of digital imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 316 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
316citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

316 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Bayesian Spatiotemporal Wombling.Journal of the American Statistical Association · 2026
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  10. Genetic analysis of imaging-derived phenotypes.Nature reviews. Genetics · 2026
    Review
  11. Article
  12. Integrating Artificial Intelligence into Prostate MR Imaging: Technical Foundations, Clinical Applications, and Workflow Implications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Review
  13. Article
  14. Article
  15. Article
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  20. Enhancing airway obstruction diagnosis with multimodal 3D shape analysis.International journal of computer assisted radiology and surgery · 2026
    Article

256 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zeynettin AkkusRadiology Informatics Lab, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Alfiia GalimzianovaDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
Assaf HoogiDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
Daniel L RubinDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
Bradley J EricksonRadiology Informatics Lab, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. bje@mayo.edu.

Funding

Qualification and Deployment of Imaging Biomarkers of Cancer Treatment ResponseU01CA190214 · NCI · STANFORD UNIVERSITY · PI RUBIN, DANIEL L · 2015 to 2020
$3.1M
Computing, Optimizing, and Evaluating Quantitative Cancer Imaging BiomarkersU01CA187947 · NCI · STANFORD UNIVERSITY · PI NAPEL, SANDY A., RUBIN, DANIEL L · 2015 to 2019
$2.9M
Computerized Quantitative Imaging Assessment of Tumor BurdenU01CA142555 · NCI · STANFORD UNIVERSITY · PI RUBIN, DANIEL L · 2010 to 2014
$2.9M
Objective decision support environment for clinical trialsU01CA160045 · NCI · MAYO CLINIC ROCHESTER · PI ERICKSON, BRADLEY J. · 2012 to 2016
$2.6M
NCI NIH HHS U01 CA142555NCI NIH HHS U01 CA160045NCI NIH HHS U01 CA187947NCI NIH HHS U01 CA190214
6 · The paper itself

Abstract

Quantitative analysis of brain MRI is routine for many neurological diseases and conditions and relies on accurate segmentation of structures of interest. Deep learning-based segmentation approaches for brain MRI are gaining interest due to their self-learning and generalization ability over large amounts of data. As the deep learning architectures are becoming more mature, they gradually outperform previous state-of-the-art classical machine learning algorithms. This review aims to provide an overview of current deep learning-based segmentation approaches for quantitative brain MRI. First we review the current deep learning architectures used for segmentation of anatomical brain structures and brain lesions. Next, the performance, speed, and properties of deep learning approaches are summarized and discussed. Finally, we provide a critical assessment of the current state and identify likely future developments and trends.

Indexed as

AlgorithmsMachine LearningBrainForecastingHumansMagnetic Resonance ImagingBrain lesion segmentationConvolutional neural networkDeep learningQuantitative brain MRI

Identifiers

PMID28577131
PMCPMC5537095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.