Trial reportJournal of immunology (Baltimore, Md. : 1950)2017
Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations.
Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Trial
- CD4 and CD8 T-cell response is dominated by IL-10-secreting cells in children with uncomplicated Plasmodium falciparum malaria.ImmunoHorizons · 2025Article
- Mucosal-Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2025Review
- Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Phenotype and function of MAIT cells in patients with alveolar echinococcosis.Frontiers in immunology · 2024Article
- Plasmodium knowlesi in pig-tailed macaques: a potential new model for malaria vaccine research.Malaria journal · 2023Article
- Colonic mucosal associated invariant T cells in Crohn's disease have a diverse and non-public T cell receptor beta chain repertoire.PloS one · 2023Article
- The Immune Signatures data resource, a compendium of systems vaccinology datasets.Scientific data · 2022Article
- Longitudinal immune profiling after radiation-attenuated sporozoite vaccination reveals coordinated immune processes correlated with malaria protection.Frontiers in immunology · 2022Article
- The role of mucosal-associated invariant T cells in visceral leishmaniasis.Frontiers in immunology · 2022Article
- Review
- Immunoprofiles associated with controlled human malaria infection and naturally acquired immunity identify a shared IgA pre-erythrocytic immunoproteome.NPJ vaccines · 2021Article
- Review
- On invariant T cells and measles: A theory of "innate immune amnesia".PLoS pathogens · 2020Article
- OMIP-064: A 27-Color Flow Cytometry Panel to Detect and Characterize Human NK Cells and Other Innate Lymphoid Cell Subsets, MAIT Cells, and γδ T Cells.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2020Article
- Human unconventional T cells in Plasmodium falciparum infection.Seminars in immunopathology · 2020Review
- Inflammatory Cytokines Induce Sustained CTLA-4 Cell Surface Expression on Human MAIT Cells.ImmunoHorizons · 2020Article
- Fast and fierce versus slow and smooth: Heterogeneity in immune responses to Plasmodium in the controlled human malaria infection model.Immunological reviews · 2020Review
- Differential IL-18 Dependence of Canonical and Adaptive NK Cells for Antibody Dependent Responses toFrontiers in immunology · 2020Article
- The Application of Single-Cell RNA Sequencing in Vaccinology.Journal of immunology research · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 7 institutions in 3 countries.
Maxmillian MpinaClinical Immunology Unit, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland.ORCID 0000-0002-9300-6430
Nicholas J MauriceVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.ORCID 0000-0002-2667-472X
Masanao YajimaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Chloe K SlichterVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Hannah W MillerVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Mukta DuttaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
M Juliana McElrathVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Kenneth D StuartCenter for Infectious Disease Research, Seattle, WA 98109.
Stephen C De RosaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
John P McNevinVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.ORCID 0000-0002-9893-9256
Peter S LinsleyBenaroya Research Institute, Seattle, WA 98101.ORCID 0000-0002-8960-4307
Salim AbdullaIfakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania; and.
Marcel TannerClinical Immunology Unit, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland.
Stephen L HoffmanSanaria Inc., Rockville, MD 20850.ORCID 0000-0002-0700-9505
Raphael GottardoVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Claudia A DaubenbergerClinical Immunology Unit, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland; Claudia.Daubenberger@unibas.ch mprlic@fhcrc.org.ORCID 0000-0001-7136-0642
Martin PrlicVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109; Claudia.Daubenberger@unibas.ch mprlic@fhcrc.org.ORCID 0000-0002-0685-9321
Fred Hutch Cancer Center · USSwiss Tropical and Public Health Institute · CHUniversity of Washington · USBoston University · USCenter for Infectious Disease Research · USIfakara Health Institute · TZSanaria · US
Funding
Bioinformatics Approach to Influenza A/H1N1 Vaccine Immune ProfilingU01AI089859 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2010 to 2015
$33.8MSystems Biology CoreU19AI128914 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI KENNETH D STUART · 2017 to 2026
$29.5MUniversal Attenuated Sporozoite Vaccine and Challenge SystemR44AI058375 · NIAID · SANARIA, INC. · PI HOFFMAN, STEPHEN LEV · 2006 to 2018
$9.9MDiseases of Public Health Importance Training GrantT32AI007509 · NIAID · UNIVERSITY OF WASHINGTON · PI LUND, JENNIFER M · 1997 to 2024
$6.3MAutomating mosquito microdissection for a malaria PfSPZ vaccineR44AI134500 · NIAID · SANARIA, INC. · PI CHAKRAVARTY, SUMANA, HOFFMAN, STEPHEN LEV · 2017 to 2023
$5.9MPaving the Way for a Novel Therapeutic Approach to Combat HIVDP2DE023321 · NIDCR · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PRLIC, MARTIN · 2012 to 2014
$2.9MImmune signatures of protection induced by whole parasite malaria vaccinesU19AI089986 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI STUART, KENNETH D · 2010 to 2015
$2.3MFHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600kNIAID NIH HHS R44 AI058375NIAID NIH HHS R44 AI134500NIAID NIH HHS T32 AI007509NIAID NIH HHS U01 AI089859NIAID NIH HHS U19 AI089986NIAID NIH HHS U19 AI128914NIDCR NIH HHS DP2 DE023321NIH HHS S10 OD020069
Abstract
Animal model studies highlight the role of innate-like lymphocyte populations in the early inflammatory response and subsequent parasite control following
Indexed as
Immunity, InnateAdultHost-Pathogen InteractionsHumansImmunity, MucosalInterferon-gammaKiller Cells, NaturalLymphocyte SubsetsMalaria, FalciparumMalaria VaccinesMaleMucosal-Associated Invariant T CellsParasitemiaPlasmodium falciparumSporozoitesTanzaniaInterferon-gammaMalaria Vaccines
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.