ArticleJournal of immunology (Baltimore, Md. : 1950)2017
Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets.
Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- SLAMF6 regulates basal T cell receptor signaling and influences invariant natural killer T cell lineage diversity.International immunology · 2025Article
- Development of αβ T Cells with Innate Functions.Advances in experimental medicine and biology · 2022Article
- Alcohol consumption induces murine osteoporosis by downregulation of natural killer T-like cell activity.Immunity, inflammation and disease · 2021Article
- Natural Killer T Lymphocytes Integrate Innate Sensory Information and Relay Context to Effector Immune Responses.Critical reviews in immunology · 2021Review
- Migration, Distribution, and Safety Evaluation of Specific Phenotypic and Functional Mouse Spleen-Derived Invariant Natural Killer T2 Cells after Adoptive Infusion.Mediators of inflammation · 2021Article
- Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis.Cell metabolism · 2020Article
- Recent advances in iNKT cell development.F1000Research · 2020Review
- Cytokine Output of Adipocyte-iNKT Cell Interplay Is Skewed by a Lipid-Rich Microenvironment.Frontiers in endocrinology · 2020Article
- Article
- Myeloid cells activate iNKT cells to produce IL-4 in the thymic medulla.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1.The EMBO journal · 2019Article
- The peripheral differentiation of human natural killer T cells.Immunology and cell biology · 2019Article
- T Cell Receptor Expression Timing and Signal Strength in the Functional Differentiation of Invariant Natural Killer T Cells.Frontiers in immunology · 2019Review
- TCR signal strength controls thymic differentiation of iNKT cell subsets.Nature communications · 2018Article
- Transcriptional and epigenetic regulation of innate-like T lymphocyte development.Current opinion in immunology · 2018Review
- Endogenous lipid antigens for invariant natural killer T cells hold the reins in adipose tissue homeostasis.Immunology · 2018Review
- IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells.Cancer immunology research · 2018Article
- How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets.Frontiers in immunology · 2018Review
- Invariant Natural Killer T Cell Subsets-More Than Just Developmental Intermediates.Frontiers in immunology · 2018Review
- Lineage Differentiation Program of Invariant Natural Killer T Cells.Immune network · 2017Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Invariant NKT (iNKT) cell functional subsets are defined by key transcription factors and output of cytokines, such as IL-4, IFN-γ, IL-17, and IL-10. To examine how TCR specificity determines iNKT function, we used somatic cell nuclear transfer to generate three lines of mice cloned from iNKT nuclei. Each line uses the invariant Vα14Jα18 TCRα paired with unique Vβ7 or Vβ8.2 subunits. We examined tissue homing, expression of PLZF, T-bet, and RORγt, and cytokine profiles and found that, although monoclonal iNKT cells differentiated into all functional subsets, the NKT17 lineage was reduced or expanded depending on the TCR expressed. We examined iNKT thymic development in limited-dilution bone marrow chimeras and show that higher TCR avidity correlates with higher PLZF and reduced T-bet expression. iNKT functional subsets showed distinct tissue distribution patterns. Although each individual monoclonal TCR showed an inherent subset distribution preference that was evident across all tissues examined, the iNKT cytokine profile differed more by tissue of origin than by TCR specificity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.