ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Descending Systems Direct Development of Key Spinal Motor Circuits.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Neuropeptides in control of left-right neural circuits.Trends in neurosciences · 2026Review
- Primitive reflexes as candidate quantitative readouts of hierarchical inhibitory control across the lifespan.Frontiers in human neuroscience · 2026Article
- Defining spinal motor neuron subtypes across development: from embryonic specification to postnatal maturation.Frontiers in cellular neuroscience · 2026Review
- The role of independent walking in the maturation of the spinal locomotor output in children with cerebral palsy.Frontiers in physiology · 2026Article
- Exploring the cortical involvement in sensorimotor integration during early stages of independent walking.Experimental brain research · 2025Article
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- The Left-Right Side-Specific Neuroendocrine Signaling from Injured Brain: An Organizational Principle.Function (Oxford, England) · 2024Article
- Motor patterns of patients with spinal muscular atrophy suggestive of sensory and corticospinal contributions to the development of locomotor muscle synergies.Journal of neurophysiology · 2024Article
- Article
- Lumbar V3 interneurons provide direct excitatory synaptic input onto thoracic sympathetic preganglionic neurons, linking locomotor, and autonomic spinal systems.Frontiers in neural circuits · 2023Article
- C-bouton components on rat extensor digitorum longus motoneurons are resistant to chronic functional overload.Journal of anatomy · 2022Article
- The left-right side-specific endocrine signaling in the effects of brain lesions: questioning of the neurological dogma.Cellular and molecular life sciences : CMLS · 2022Review
- Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.Nature communications · 2022Article
- Caudal-Rostral Progression of Alpha Motoneuron Degeneration in the SOD1Antioxidants (Basel, Switzerland) · 2022Article
- Heterogeneity in form and function of the rat extensor digitorum longus motor unit.Journal of anatomy · 2022Article
- Saccharomyces boulardii improves the behaviour and emotions of spastic cerebral palsy rats through the gut-brain axis pathway.BMC neuroscience · 2021Article
- Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood.Scientific reports · 2021Article
- Article
- Semaphorin 7A restricts serotonergic innervation and ensures recovery after spinal cord injury.Cellular and molecular life sciences : CMLS · 2021Article
- Spinal motoneuron firing properties mature from rostral to caudal during postnatal development of the mouse.The Journal of physiology · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of mature spinal motor circuits is dependent on both activity-dependent and independent mechanisms during postnatal development. During this time, reorganization and refinement of spinal sensorimotor circuits occurs as supraspinal projections are integrated. However, specific features of postnatal spinal circuit development remain poorly understood. This study provides the first detailed characterization of rat spinal sensorimotor circuit development in the presence and absence of descending systems. We show that the development of proprioceptive afferent input to motoneurons (MNs) and Renshaw cells (RCs) is disrupted by thoracic spinal cord transection at postnatal day 5 (P5TX). P5TX also led to malformation of GABApre neuron axo-axonic contacts on Ia afferents and of the recurrent inhibitory circuit between MNs and RCs. Using a novel
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