ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Binocular Disparity Selectivity Weakened after Monocular Deprivation in Mouse V1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Eye-specific drive and binocular suppression in mouse visual cortex during critical period development.bioRxiv : the preprint server for biology · 2026Article
- Circuit dynamics of binocular conflict in mouse primary visual cortex.Frontiers in systems neuroscience · 2026Article
- A Critical Look at Critical Periods.Annual review of vision science · 2025Review
- Responses to conflicting binocular stimuli in mouse primary visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Experience-dependent plasticity of multiple receptive field properties in lateral geniculate binocular neurons during the critical period.Frontiers in cellular neuroscience · 2025Article
- Interactions between excitatory neurons and parvalbumin interneurons in V1 underlie neural mechanisms of amblyopia and visual stimulation treatment.Communications biology · 2024Article
- Mammals Achieve Common Neural Coverage of Visual Scenes Using Distinct Sampling Behaviors.eNeuro · 2024Article
- Monocular deprivation during the critical period alters neuronal tuning and the composition of visual circuitry.PLoS biology · 2023Article
- Neural circuits for binocular vision: Ocular dominance, interocular matching, and disparity selectivity.Frontiers in neural circuits · 2023Review
- Binocular visual experience drives the maturation of response variability and reliability in the visual cortex.iScience · 2022Article
- The Development of Receptive Field Tuning Properties in Mouse Binocular Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Chronic Monocular Deprivation Reveals MMP9-Dependent and -Independent Aspects of Murine Visual System Plasticity.International journal of molecular sciences · 2022Article
- Binocular integration of retinal motion information underlies optic flow processing by the cortex.Current biology : CB · 2021Article
- Portrait of visual cortical circuits for generating neural oscillation dynamics.Cognitive neurodynamics · 2021Review
- New Progress on Binocular Disparity in Higher Visual Areas Beyond V1.Neuroscience bulletin · 2020Article
- Interocular velocity cues elicit vergence eye movements in mice.Journal of neurophysiology · 2020Article
- Article
- Experience-Dependent Development and Maintenance of Binocular Neurons in the Mouse Visual Cortex.Cell reports · 2020Article
- Long-term Monocular Deprivation during Juvenile Critical Period Disrupts Binocular Integration in Mouse Visual Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Mesoscopic Mapping of Stimulus-Selective Response Plasticity in the Visual Pathways Modulated by the Cholinergic System.Frontiers in neural circuits · 2020Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Experiences during the critical period sculpt the circuitry within the neocortex, leading to changes in the functional responses of sensory neurons. Monocular deprivation (MD) during the visual critical period causes shifts in ocular preference, or dominance, toward the open eye in primary visual cortex (V1) and disrupts the normal development of acuity. In carnivores and primates, MD also disrupts the emergence of binocular disparity selectivity, a cue resulting from integrating ocular inputs. This disruption may be a result of the increase in neurons driven exclusively by the open eye that follows deprivation or a result of a mismatch in the convergence of ocular inputs. To distinguish between these possibilities, we measured the ocular dominance (OD) and disparity selectivity of neurons from male and female mouse V1 following MD. Normal mouse V1 neurons are dominated by contralateral eye input and contralateral eye deprivation shifts mouse V1 neurons toward more balanced responses between the eyes. This shift toward binocularity, as assayed by OD, decreased disparity sensitivity. MD did not alter the initial maturation of binocularity, as disparity selectivity before the MD was indistinguishable from normal mature animals. Decreased disparity tuning was most pronounced in binocular and ipsilaterally biased neurons, which are the populations that have undergone the largest shifts in OD. In concert with the decline in disparity selectivity, we observed a shift toward lower spatial frequency selectivity for the ipsilateral eye following MD. These results suggest an emergence of novel synaptic inputs during MD that disrupt the representation of disparity selectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.