Observational studyClinical journal of the American Society of Nephrology : CJASN2017
Low Bone Density and Bisphosphonate Use and the Risk of Kidney Stones.
Observational study in Clinical journal of the American Society of Nephrology : CJASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Hypophosphatemia in kidney stone formers.Current opinion in nephrology and hypertension · 2026Review
- Combined occurrence of cardiovascular and bone events in individuals with kidney stone disease.Clinical kidney journal · 2026Article
- Plasma metabolomic profiles and risk of hip fracture among US individuals: a nested case-control and prospective cohort study.EBioMedicine · 2026Article
- Exploring the association between osteoporosis and kidney stones: a clinical to mechanistic translational study based on big data and bioinformatics.Biology direct · 2025Article
- Between a Rock and a Short Place-The Impact of Nephrolithiasis on Skeletal Growth and Development Across the Lifespan.Current osteoporosis reports · 2024Review
- Vitamins as regulators of calcium-containing kidney stones - new perspectives on the role of the gut microbiome.Nature reviews. Urology · 2023Review
- 24-h Urinary Calcium Excretion and Renal Outcomes in Hospitalized Patients with and without Chronic Kidney Disease.Journal of clinical medicine · 2023Article
- Article
- Self-reported sleep characteristics and risk for incident vertebral and hip fracture in women.Sleep health · 2022Article
- Numerical characterization of astronaut CaOx renal stone incidence rates to quantify in-flight and post-flight relative risk.NPJ microgravity · 2022Article
- Osteoporosis, bisphosphonate use, and risk of moderate or worse hearing loss in women.Journal of the American Geriatrics Society · 2021Article
- Osteoporosis is a Predictive Factor for Nephrolithiasis in an Adult Free-Living Caucasian Population From Southern Italy: A Longitudinal Retrospective Study Based on a General Practice Database.Calcified tissue international · 2020Article
- Obstructive Sleep Apnea and Risk for Incident Vertebral and Hip Fracture in Women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Idiopathic Osteoporosis and Nephrolithiasis: Two Sides of the Same Coin?International journal of molecular sciences · 2020Review
- Article
- Effect of bisphosphonates on the crystallization of stone-forming salts in synthetic urine.Investigative and clinical urology · 2020Article
- BMI, Waist Circumference, and Risk of Incident Vertebral Fracture in Women.Obesity (Silver Spring, Md.) · 2019Article
- Empiric therapy for kidney stones.Urolithiasis · 2019Review
- A Short Review on the Relationships Between Nephrolithiasis and Myocardial Infarction.Galen medical journal · 2019Review
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
objectivesPrevious studies have demonstrated lower bone density in patients with kidney stones, but no longitudinal studies have evaluated kidney stone risk in individuals with low bone density. Small studies with short follow-up reported reduced 24-hour urine calcium excretion with bisphosphonate use. We examined history of low bone density and bisphosphonate use and the risk of incident kidney stone as well as the association with 24-hour calcium excretion. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a prospective analysis of 96,092 women in the Nurses' Health Study II. We used Cox proportional hazards models to adjust for age, body mass index, thiazide use, fluid intake, supplemental calcium use, and dietary factors. We also conducted a cross-sectional analysis of 2294 participants using multivariable linear regression to compare 24-hour urinary calcium excretion between participants with and without a history of low bone density, and among 458 participants with low bone density, with and without bisphosphonate use.
resultsWe identified 2564 incident stones during 1,179,860 person-years of follow-up. The multivariable adjusted relative risk for an incident kidney stone for participants with history of low bone density compared with participants without was 1.39 (95% confidence interval [95% CI], 1.20 to 1.62). Among participants with low bone density, the multivariable adjusted relative risk for an incident kidney stone for bisphosphonate users was 0.68 (95% CI, 0.48 to 0.98). In the cross-sectional analysis of 24-hour urine calcium excretion, the multivariable adjusted mean difference in 24-hour calcium was 10 mg/d (95% CI, 1 to 19) higher for participants with history of low bone density. However, among participants with history of low bone density, there was no association between bisphosphonate use and 24-hour calcium with multivariable adjusted mean difference in 24-hour calcium of -2 mg/d (95% CI, -25 to 20).
conclusionsLow bone density is an independent risk factor for incident kidney stone and is associated with higher 24-hour urine calcium excretion. Among participants with low bone density, bisphosphonate use was associated with lower risk of incident kidney stone but was not independently associated with 24-hour urine calcium excretion.
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