Evidence map›Paper›PMID 28576882›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Modeling gene regulation from paired expression and chromatin accessibility data.

Zhana Duren, Xi Chen, Rui Jiang, Yong Wang, Wing Hung Wong

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 222 citations in OpenAlex.

  1. Inferring Gene Regulatory Networks in Stem Cells: Methods and Applications.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Zhana DurenAcademy of Mathematics and Systems Science, National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Beijing 100080, China.
Xi ChenDepartment of Statistics, Department of Biomedical Data Science, Bio-X Program, Stanford University, Stanford, CA 94305.
Rui JiangMinistry of Education Key Laboratory of Bioinformatics, Bioinformatics Division and Center for Synthetic & Systems Biology, Tsinghua National Laboratory for Information Science and Technology, Department of Automation, Tsinghua University, Beijing 100084, China ywang@amss.ac.cn ruijiang@tsinghua.edu.cn whwong@stanford.edu.
Yong WangAcademy of Mathematics and Systems Science, National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Beijing 100080, China; ywang@amss.ac.cn ruijiang@tsinghua.edu.cn whwong@stanford.edu.
Wing Hung WongDepartment of Statistics, Department of Biomedical Data Science, Bio-X Program, Stanford University, Stanford, CA 94305; ywang@amss.ac.cn ruijiang@tsinghua.edu.cn whwong@stanford.edu.
Stanford University · USAcademy of Mathematics and Systems Science · CNTsinghua University · CNUniversity of Chinese Academy of Sciences · CN

Funding

Special EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2M
Statistical and computational analysis in whole genome sequencing studies.R01HG007834 · NHGRI · STANFORD UNIVERSITY · PI WONG, WING H. · 2014 to 2016
$892k
NHGRI NIH HHS P50 HG007735NHGRI NIH HHS R01 HG007834
6 · The paper itself

Abstract

The rapid increase of genome-wide datasets on gene expression, chromatin states, and transcription factor (TF) binding locations offers an exciting opportunity to interpret the information encoded in genomes and epigenomes. This task can be challenging as it requires joint modeling of context-specific activation of

Indexed as

AnimalsBinding SitesChromatinChromatin Assembly and DisassemblyEnhancer Elements, GeneticGene Expression RegulationGene Regulatory NetworksHumansMiceProtein BindingRegulatory Elements, TranscriptionalTranscription FactorsChromatinTranscription Factorschromatin activitychromatin regulatorgene regulationregulatory elementtranscription factor

Identifiers

PMID28576882
PMCPMC5488952
OpenAlexW2621109613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.