Evidence map›Paper›PMID 28576878›Full record

ArticleBlood2017

The disulfide isomerase ERp72 supports arterial thrombosis in mice.

Junsong Zhou, Yi Wu, Fengwu Chen, Lu Wang, Lubica Rauova, Vincent M Hayes, Mortimer Poncz, Hong Li, Tong Liu, Junling Liu and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Review
  3. Mechanochemistry: Fundamental Principles and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Thiol isomerase ERp18 enhances platelet activation and arterial thrombosis.Research and practice in thrombosis and haemostasis · 2025
    Article
  10. Platelets welcome a new protein disulfide isomerase family member.Journal of thrombosis and haemostasis : JTH · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Junsong ZhouThe Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Yi WuThe Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Fengwu ChenThe Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Lu WangSol Sherry Thrombosis Research Center, Division of Hematology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA.
Lubica RauovaDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.
Vincent M HayesDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.
Mortimer PonczDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.
Hong LiCenter For Advanced Proteomics Research, New Jersey Medical School, Rutgers University, Newark, NJ; and.
Tong LiuCenter For Advanced Proteomics Research, New Jersey Medical School, Rutgers University, Newark, NJ; and.
Junling LiuDepartment of Biochemistry and Molecular and Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institute of Medical Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
David W EssexSol Sherry Thrombosis Research Center, Division of Hematology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA.ORCID 0000-0002-8758-0663
Children's Hospital of Philadelphia · USSoochow University · CNRutgers, The State University of New Jersey · USTemple University · USShanghai Jiao Tong University · CN

Funding

Protein CoreP01HL110860 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI RAUOVA, LUBICA · 2012 to 2016
$11.4M
Rutgers Mass Spectrometry Core for Integrative Neuroscience ResearchP30NS046593 · NINDS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI LOBEL, PETER · 2004 to 2018
$9.9M
Functional Role of Protein Disulfide Isomerase Isoforms in PlateletsR01HL118526 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ESSEX, DAVID W · 2013 to 2021
$4.4M
NO signaling by a Soluble Guanylyl Cyclase-Thioredoxin transnitrosation complexR01GM112415 · NIGMS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI BEUVE, ANNIE V · 2015 to 2023
$3.5M
NHLBI NIH HHS P01 HL110860NHLBI NIH HHS R01 HL118526NIGMS NIH HHS R01 GM112415NINDS NIH HHS P30 NS046593
6 · The paper itself

Abstract

Several CGHC motif-containing disulfide isomerases support thrombosis. We here report that endoplasmic reticulum protein 72 (ERp72), with 3 CGHC redox-active sites (a

Indexed as

AnimalsBlood PlateletsHumansMembrane GlycoproteinsMiceMice, KnockoutPlatelet ActivationPlatelet Glycoprotein GPIIb-IIIa ComplexThrombosisendoplasmic reticulum glycoprotein p72Membrane GlycoproteinsPlatelet Glycoprotein GPIIb-IIIa Complex

Identifiers

PMID28576878
PMCPMC5553574
OpenAlexW2621264327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.