ArticleBlood2017
Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway.
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Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Impaired cellular trafficking of a thrombomodulin mutant causes severe bleeding, thrombosis, and atypical hemolytic uremic syndrome.Blood vessels, thrombosis & hemostasis · 2026Article
- A sensitized model of thrombosis validates known multigenic relationships and suggests novel modifiers of hemostasis.bioRxiv : the preprint server for biology · 2026Article
- Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.Blood advances · 2025Article
- Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesis.Blood advances · 2025Article
- Real-time imaging of blood coagulation and angiogenesis during development in a zebrafish model of type I antithrombin deficiency.Scientific reports · 2025Article
- Loss of protein C vs protein S results in discrepant thrombotic phenotypes.Blood advances · 2025Article
- Hormone-induced thrombosis is mediated through non-canonical fibrin(ogen) aggregation and a novel estrogen target in zebrafish.bioRxiv : the preprint server for biology · 2024Article
- SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function.EMBO reports · 2024Article
- Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesis.bioRxiv : the preprint server for biology · 2024Article
- Article
- Genetic duplication of tissue factor reveals subfunctionalization in venous and arterial hemostasis.PLoS genetics · 2022Article
- Fishing for answers to hemostatic and thrombotic disease: Genome editing in zebrafish.Research and practice in thrombosis and haemostasis · 2022Review
- Venous Thrombosis and Thrombocyte Activity in Zebrafish Models of Quantitative and Qualitative Fibrinogen Disorders.International journal of molecular sciences · 2021Article
- Functional Verification of NovelFrontiers in cell and developmental biology · 2021Article
- A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis.Blood advances · 2020Article
- Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease.Human molecular genetics · 2020Article
- Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish.Scientific reports · 2020Article
- Analysis of factor V in zebrafish demonstrates minimal levels needed for early hemostasis.Blood advances · 2019Article
- Loss of fibrinogen in zebrafish results in an asymptomatic embryonic hemostatic defect and synthetic lethality with thrombocytopenia.Journal of thrombosis and haemostasis : JTH · 2019Article
- Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish.Blood advances · 2018Article
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Authors and funding
13 authors at 5 institutions in 3 countries.
Zhilian HuDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-1632-6318
Yang LiuDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
Michael C HuarngDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
Marzia MenegattiAngelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-8527-7556
Deepak ReyonMolecular Pathology Unit, Center for Computational and Integrative Biology, and.
Megan S RostDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
Zachary G NorrisDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
Catherine E RichterDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
Alexandra N StapletonDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
Neil C ChiDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA.
Flora PeyvandiAngelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0001-7423-9864
J Keith JoungMolecular Pathology Unit, Center for Computational and Integrative Biology, and.
Jordan A ShavitDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-2874-4904
University of Michigan · USHarvard University · USFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of California San Diego · USUniversity of Milan · IT
Funding
Training Program in Molecular HematologyT32HL007622 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUNG WON CHOI, Jordan A. Shavit · 1986 to 2026
$9.2MADVANCING ZINC FINGER NUCLEASES FOR TARGETED GENOME MANIPULATIONR01GM088040 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI JOUNG, J. KEITH, PETERSON, RANDALL T · 2009 to 2016
$4.5MDissecting the Genetics of Human Hemostatic Disorders Using ZebrafishR01HL124232 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAVIT, JORDAN A · 2015 to 2019
$1.9MNHLBI NIH HHS R01 HL124232NHLBI NIH HHS T32 HL007622NIGMS NIH HHS R01 GM088040
Abstract
Deficiency of factor X (F10) in humans is a rare bleeding disorder with a heterogeneous phenotype and limited therapeutic options. Targeted disruption of
Indexed as
Factor XGene EditingMutationZebrafishZebrafish ProteinsAnimalsBlood CoagulationFactor X DeficiencyHumansMiceFactor XZebrafish Proteins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.