Evidence map›Paper›PMID 28576863›Full record

ArticleGenetics2017

Evolving Mistranslating tRNAs Through a Phenotypically Ambivalent Intermediate in

Matthew D Berg, Kyle S Hoffman, Julie Genereaux, Safee Mian, Ryan S Trussler, David B Haniford, Patrick O'Donoghue, Christopher J Brandl

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Mistranslating tRNA variants impact the proteome and phosphoproteome ofbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Mistranslating tRNA variants have anticodon- and sex-specific impacts onbioRxiv : the preprint server for biology · 2024
    Article
  9. Article
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  12. Article
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  16. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Matthew D BergDepartment of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada mberg2@uwo.ca cbrandl@uwo.ca.ORCID 0000-0002-7924-9241
Kyle S HoffmanDepartment of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.ORCID 0000-0003-0170-2090
Julie GenereauxDepartment of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
Safee MianDepartment of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.ORCID 0000-0002-9062-492X
Ryan S TrusslerDepartment of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
David B HanifordDepartment of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
Patrick O'DonoghueDepartment of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
Christopher J BrandlDepartment of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada mberg2@uwo.ca cbrandl@uwo.ca.ORCID 0000-0001-8015-9668
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genetic code converts information from nucleic acid into protein. The genetic code was thought to be immutable, yet many examples in nature indicate that variations to the code provide a selective advantage. We used a sensitive selection system involving suppression of a deleterious allele (

Indexed as

Evolution, MolecularCodonMolecular ChaperonesMutationPhenotypeProtein BiosynthesisRNA StabilityRNA, Transfer, ProSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCodonMolecular ChaperonesRNA, Transfer, ProSaccharomyces cerevisiae ProteinsTti2 protein, S cerevisiaeanticodongenetic selectionmistranslationtRNA

Identifiers

PMID28576863
PMCPMC5560794
OpenAlexW2620574740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.