Evidence map›Paper›PMID 28576852›Full record

ArticlePhysiological reports2017

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease.

Tamara S Cutler, Saemi Park, Dawn H Loh, Maria C Jordan, Tomohiro Yokota, Kenneth P Roos, Cristina A Ghiani, Christopher S Colwell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Systemic Symptoms in Huntington's Disease: A Comprehensive Review.Movement disorders clinical practice · 2024
    Pooled it
  2. Review
  3. Cardiac autonomic involvement in Huntington's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  4. Review
  5. Autonomic disorders and myocardial 123I-metaiodobenzylguanidine scintigraphy in Huntington's disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  6. Article
  7. Article
  8. Defining circadian disruption in neurodegenerative disorders.The Journal of clinical investigation · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tamara S CutlerDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Saemi ParkDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Dawn H LohDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Maria C JordanDepartment of Physiology and Cardiovascular Research Lab, University of California, Los Angeles, Los Angeles, California.
Tomohiro YokotaDepartment of Anesthesiology, Division of Molecular Medicine David Geffen School of Medicine University of California, Los Angeles, Los Angeles, California.
Kenneth P RoosDepartment of Physiology and Cardiovascular Research Lab, University of California, Los Angeles, Los Angeles, California.
Cristina A GhianiDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Christopher S ColwellDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California ccolwell@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-1059-184X
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular dysautonomia as well as the deterioration of circadian rhythms are among the earliest detectable pathophysiological changes in individuals with Huntington's disease (HD). Preclinical research requires mouse models that recapitulate disease symptoms and the Q175 knock-in model offers a number of advantages but potential autonomic dysfunction has not been explored. In this study, we sought to test the dual hypotheses that cardiovascular dysautonomia can be detected early in disease progression in the Q175 model and that this dysfunction varies with the daily cycle. Using radiotelemetry implants, we observed a significant reduction in the diurnal and circadian activity rhythms in the Q175 mutants at the youngest ages. By middle age, the autonomically driven rhythms in core body temperature were highly compromised, and the Q175 mutants exhibited striking episodes of hypothermia that increased in frequency with mutant

Indexed as

AnimalsAutonomic Nervous SystemBaroreflexBlood PressureBody TemperatureCircadian RhythmHeartHeart RateHuntingtin ProteinHuntington DiseaseMaleMiceMice, Inbred C57BLMutationStroke VolumeHtt protein, mouseHuntingtin ProteinAutonomic nervous systembaroreceptor reflexcardiovascular functioncircadian rhythmscore body temperatureechocardiogramselectrocardiogramsfibrosisheart rate variabilityHuntington's diseaseradio telemetry

Identifiers

PMID28576852
PMCPMC5471434
OpenAlexW2620846611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.