Evidence map›Paper›PMID 28576851›Full record

ArticlePhysiological reports2017

Urinary Tamm-Horsfall protein, albumin, vitamin D-binding protein, and retinol-binding protein as early biomarkers of chronic kidney disease in dogs.

Fernanda Chacar, Márcia Kogika, Talita R Sanches, Douglas Caragelasco, Cínthia Martorelli, Camila Rodrigues, Jose Manuel C Capcha, Dennis Chew, Lúcia Andrade

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 78 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Renal Biomarkers in Companion Animals-A Review.Animals : an open access journal from MDPI · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Serum uromodulin in dogs with chronic kidney disease.Journal of veterinary internal medicine · 2022
    Article
  12. Article
  13. Article
  14. Reference intervals for electrophoretograms obtained by capillary electrophoresis of dialyzed urine from healthy dogs.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Fernanda ChacarDepartment of Veterinary Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil fernandachicharo@usp.br.
Márcia KogikaDepartment of Veterinary Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Talita R SanchesDivision of Nephrology, School of Medicine, University of São Paulo, São Paulo, Brazil.
Douglas CaragelascoDepartment of Veterinary Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Cínthia MartorelliDepartment of Veterinary Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Camila RodriguesDivision of Nephrology, School of Medicine, University of São Paulo, São Paulo, Brazil.
Jose Manuel C CapchaDivision of Nephrology, School of Medicine, University of São Paulo, São Paulo, Brazil.
Dennis ChewDepartment of Veterinary Clinical Sciences, Ohio State University, Columbus, Ohio.
Lúcia AndradeDivision of Nephrology, School of Medicine, University of São Paulo, São Paulo, Brazil.
Universidade de São Paulo · BRThe Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteinuria is a marker and mediator of chronic kidney disease (CKD). In clinical practice, the urinary protein-to-creatinine ratio (UP/C) is of limited usefulness, because it indicates only the magnitude of proteinuria and not the origin of the loss (glomerular or tubular). The complete assessment of proteinuria includes quantitative and qualitative evaluations, both of which are required in order to optimize the therapy. In addition to measuring the UP/C, we performed SDS-PAGE and western blotting to determine the expression of albumin, vitamin D-binding protein (VDBP), retinol-binding protein (RBP), and Tamm-Horsfall protein (THP) in urine samples of 49 dogs: healthy (control) dogs (

Indexed as

AnimalsBiomarkersDogsFemaleMaleProteinuriaRenal Insufficiency, ChronicRetinol-Binding ProteinsUromodulinVitamin D-Binding ProteinBiomarkersRetinol-Binding ProteinsUromodulinVitamin D-Binding ProteinChronic kidney diseasedogsretinol‐binding proteinTamm‐Horsfall proteinvitamin D‐binding protein

Identifiers

PMID28576851
PMCPMC5471429
OpenAlexW2620729708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.