Evidence map›Paper›PMID 28576771›Full record

ArticleDevelopment (Cambridge, England)2017

BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice.

Jifan Feng, Junjun Jing, Jingyuan Li, Hu Zhao, Vasu Punj, Tingwei Zhang, Jian Xu, Yang Chai

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 84 citations in OpenAlex.

  1. Targeting Gli1Stem cell reviews and reports · 2026
    Review
  2. Human CD24Nature communications · 2026
    Article
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  12. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
  15. A spatially organizedScience advances · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Bone or Tooth dentin: The TGF-β signaling is the key.International journal of biological sciences · 2024
    Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Jifan FengCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
Junjun JingCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
Jingyuan LiCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
Hu ZhaoCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
Vasu PunjDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Tingwei ZhangCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
Jian XuCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
Yang ChaiCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA ychai@usc.edu.ORCID 0000-0002-8943-0861
University of Southern California · US

Funding

THE MOLECULAR REGULATORY MECHANISM OF TOOTH ROOT DEVELOPMENTR01DE022503 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Yang Chai · 2012 to 2026
$6.2M
TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESISR37DE012711 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHAI, YANG · 2009 to 2018
$4.3M
MOLECULAR REGULATORY MECHANISM OF MESENCHYMAL STEM CELLS IN ADULT MOUSE INCISORSR01DE025221 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Yang Chai · 2016 to 2026
$4.3M
DOCTORAL AND POST-DOCTORAL TRAINING IN CRANIOFACIAL BIOLOGYR90DE022528 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAINE, MICHAEL LANSDELL · 2011 to 2025
$1.3M
NIDCR NIH HHS R01 DE022503NIDCR NIH HHS R01 DE025221NIDCR NIH HHS R37 DE012711NIDCR NIH HHS R90 DE022528
6 · The paper itself

Abstract

Signaling pathways are used reiteratively in different developmental processes yet produce distinct cell fates through specific downstream transcription factors. In this study, we used tooth root development as a model with which to investigate how the BMP signaling pathway regulates transcriptional complexes to direct the fate determination of multipotent mesenchymal stem cells (MSCs). We first identified the MSC population supporting mouse molar root growth as Gli1

Indexed as

AnimalsBone Morphogenetic ProteinsCell DifferentiationCell LineageFemaleGene Regulatory NetworksKruppel-Like Factor 4MaleMesenchymal Stem CellsMiceMice, TransgenicOdontoblastsOdontogenesisRegenerationSignal TransductionStem Cell NicheBone Morphogenetic ProteinsGli1 protein, mouseKlf4 protein, mouseKruppel-Like Factor 4Transcription FactorsZinc Finger Protein GLI1BMPGli1Mesenchymal stem cells (MSCs)Odontogenesis

Identifiers

PMID28576771
PMCPMC5536932
OpenAlexW2951812160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.