Evidence map›Paper›PMID 28576511›Full record

ReviewNeuroscience and biobehavioral reviews2018

Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation.

Patricia B de la Tremblaye, Darik A O'Neil, Megan J LaPorte, Jeffrey P Cheng, Joshua A Beitchman, Theresa Currier Thomas, Corina O Bondi, Anthony E Kline

Open access · bronzeAbstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  4. Drosophila as a model to explore secondary injury cascades after traumatic brain injury.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Patricia B de la TremblayeDepartment of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States.
Darik A O'NeilDepartment of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States.
Megan J LaPorteDepartment of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States.
Jeffrey P ChengDepartment of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States.
Joshua A BeitchmanBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, United States; Department of Child Health, University of Arizona College of Medicine, Phoenix, AZ, United States; Midwestern University, Glendale, AZ, United States.
Theresa Currier ThomasBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, United States; Department of Child Health, University of Arizona College of Medicine, Phoenix, AZ, United States; Phoenix VA Healthcare System, Phoenix, AZ, United States.
Corina O BondiDepartment of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, United States.
Anthony E KlineDepartment of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, United States; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: klineae@upmc.edu.
University of Pittsburgh · USCenter for the Neural Basis of Cognition · USPhoenix VA Health Care System · USUniversity of Arizona · US

Funding

Training in the Neurobiology of Neurological DiseaseT32NS086749 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Omar El Gharbawie, REBECCA P SEAL · 2014 to 2026
$4.8M
Optimizing Environmental Enrichment to Model Preclinical NeurorehabilitationR01NS084967 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2014 to 2025
$3.7M
Environmental Enrichment and Cholinergic Mechanisms after TBIR01NS060005 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2009 to 2013
$1.6M
Understanding the Impact of Antipsychotic Drugs on Recovery After TBIR01HD069620 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2012 to 2016
$1.6M
Effects of Chronic Adolescent Stress on Cognitive and Emotional Behavior After Adult TBIR21NS099674 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2017 to 2018
$429k
Multimodal Assessment of Behavioral flexibility after Frontal Brain TraumaR21NS099683 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BONDI, CORINA OANA · 2016 to 2017
$426k
Sustained Attention and Executive Functioning After Brain TraumaR03NS094950 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BONDI, CORINA OANA · 2016 to 2017
$154k
NICHD NIH HHS R01 HD069620NINDS NIH HHS R01 NS060005NINDS NIH HHS R01 NS084967NINDS NIH HHS R03 NS094950NINDS NIH HHS R21 NS099674NINDS NIH HHS R21 NS099683NINDS NIH HHS T32 NS086749
6 · The paper itself

Abstract

The aim of this review is to discuss the research presented in a symposium entitled "Current progress in characterizing therapeutic strategies and challenges in experimental CNS injury" which was presented at the 2016 International Behavioral Neuroscience Society annual meeting. Herein we discuss diffuse and focal traumatic brain injury (TBI) and ensuing chronic behavioral deficits as well as potential rehabilitative approaches. We also discuss the effects of stress on executive function after TBI as well as the response of the endocrine system and regulatory feedback mechanisms. The role of the endocannabinoids after CNS injury is also discussed. Finally, we conclude with a discussion of antipsychotic and antiepileptic drugs, which are provided to control TBI-induced agitation and seizures, respectively. The review consists predominantly of published data.

Indexed as

AnimalsAntipsychotic AgentsBrain Injuries, TraumaticDisease Models, AnimalHippocampusHumansMaze LearningRecovery of FunctionAntipsychotic AgentsAntiepileptic drugs (AEDs)Antipsychotic drugs (APDs)Controlled cortical impact (CCI)EndocannabinoidsExecutive functionFluid percussion (FP) injuryMorris water maze (MWM)RehabilitationStressTraumatic brain injury (TBI)

Identifiers

PMID28576511
PMCPMC5709241
OpenAlexW2617237232

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.