Evidence map›Paper›PMID 28576172›Full record

ReviewPET clinics2017

Multimodal PET Imaging of Amyloid and Tau Pathology in Alzheimer Disease and Non-Alzheimer Disease Dementias.

Chenjie Xia, Bradford C Dickerson

Abstract readReview
In one paragraph

Review in PET clinics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Neuroimaging in aging and neurologic diseases.Handbook of clinical neurology · 2019
    Review
  10. Beta-amyloid imaging in dementia.Yeungnam University journal of medicine · 2018
    Review
  11. Article
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Chenjie XiaDepartment of Neurology, Jewish General Hospital, McGill University, 3755 Chemin de la Côte-Sainte-Catherine Road, Suite E-005, Montreal, QC H3T 1E2, Canada.
Bradford C DickersonFrontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard University, 149 13th Street, Suite 2691, Charlestown, Boston, MA 02129, USA. Electronic address: brad.dickerson@mgh.harvard.edu.
Jewish General Hospital · CAMassachusetts General Hospital · US

Funding

Imaging tau, amyloid, and neurodegeneration in PPAR01DC014296 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI DICKERSON, BRADFORD C, JOHNSON, KEITH A. · 2016 to 2020
$4.3M
NIDCD NIH HHS R01 DC014296
6 · The paper itself

Abstract

Biomarkers of the molecular pathology underpinning dementia syndromes are increasingly recognized as crucial for diagnosis and development of disease-modifying treatments. Amyloid PET imaging is an integral part of the diagnostic assessment of Alzheimer disease. Its use has also deepened understanding of the role of amyloid pathology in Lewy body disorders and aging. Tau PET imaging is an imaging biomarker that will likely play an important role in the diagnosis, monitoring, and treatment in dementias. Using tau PET imaging to examine how tau pathology relates to amyloid and other markers of neurodegeneration will serve to better understand the pathophysiologic cascade that leads to dementia.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesDementiaHumansMultimodal ImagingParkinson DiseasePositron-Emission TomographyRadiopharmaceuticalstau ProteinsTomography, X-Ray ComputedAmyloid beta-PeptidesRadiopharmaceuticalstau ProteinsAlzheimer diseaseAmyloid PET imagingBiomarkerDementiaTau PET imaging

Identifiers

PMID28576172
PMCPMC5690983
OpenAlexW2605550306

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.