Evidence map›Paper›PMID 28576127›Full record

SynthesisCritical care (London, England)2017

Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis.

Karen E A Burns, Ibrahim Soliman, Neill K J Adhikari, Amer Zwein, Jessica T Y Wong, Carolina Gomez-Builes, Jose Augusto Pellegrini, Lu Chen, Nuttapol Rittayamai, Michael Sklar and 2 more

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical care (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04939285 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Effect of PEEP=5cmH2O vs PEEP=0cmH2O PSV Strategies During SBT on Successful Disconnection From Mechanical Ventilation: A Randomized Clinical Trial

TypeinterventionalSponsorFirst Affiliated Hospital, Sun Yat-Sen UniversityRan2020 to 2021Enrolled50ConditionsRespiration, ArtificialArmsPEEP
NCT04987398 completednot on this mapstarted 2021, after this paper: background citation

Analysis of Ventilation Weaning Strategies and Correlation to Outcomes in Tracheostomized Patients in the Intensive Care Unit of the Lausanne University Hospital

TypeobservationalSponsorPiquilloud Imboden LiseRan2021 to 2022Enrolled80ConditionsRespiratory Failure, Tracheostomy Complication
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  8. Comparison of the timed inspiratory effort index with the T-piece trial as a decision-making tool for extubation: a randomized controlled non-inferiority trial.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karen E A BurnsSt Michael's Hospital and the Keenan Research Centre/Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.
Ibrahim SolimanSt Michael's Hospital and the Keenan Research Centre/Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.
Neill K J AdhikariInterdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
Amer ZweinSt Michael's Hospital and the Keenan Research Centre/Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.
Jessica T Y WongDepartment of Public Health, University of Toronto, Toronto, ON, Canada.
Carolina Gomez-BuilesSt Michael's Hospital and the Keenan Research Centre/Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.
Jose Augusto PellegriniDivision of Critical Care of Moinhos de Vento Hospital, Porto Alegre, Brazil.
Lu ChenSt Michael's Hospital and the Keenan Research Centre/Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.
Nuttapol RittayamaiSt Michael's Hospital and the Keenan Research Centre/Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.
Michael SklarSt Michael's Hospital and the Keenan Research Centre/Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.
Laurent J BrochardSt Michael's Hospital and the Keenan Research Centre/Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.
Jan O FriedrichSt Michael's Hospital and the Keenan Research Centre/Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON, M5B 1W8, Canada. friedrichj@smh.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effect of alternative spontaneous breathing trial (SBT) techniques on extubation success and other clinically important outcomes is uncertain.

methodsWe searched MEDLINE, EMBASE, CENTRAL, CINAHL, Evidence-Based Medicine Reviews, Ovid Health Star, proceedings of five conferences (1990-2016), and reference lists for randomized trials comparing SBT techniques in intubated adults or children. Primary outcomes were initial SBT success, extubation success, or reintubation. Two reviewers independently screened citations, assessed trial quality, and abstracted data.

resultsWe identified 31 trials (n = 3541 patients). Moderate-quality evidence showed that patients undergoing pressure support (PS) compared with T-piece SBTs (nine trials, n = 1901) were as likely to pass an initial SBT (risk ratio (RR) 1.00, 95% confidence interval (CI) 0.89-1.11; I

conclusionsPatients undergoing PS (vs T-piece) SBTs appear to be 6% (95% CI 2-10%) more likely to be extubated successfully and, if the results of an outlier trial are excluded, 6% (95% CI 1-12%) more likely to pass an SBT. Future trials should investigate patients for whom SBT and extubation outcomes are uncertain and compare techniques that maximize differences in support.

Indexed as

Severity of Illness IndexAirway ExtubationHumansIntubation, IntratrachealRespiration, ArtificialVentilator WeaningExtubationExtubation outcomeMeta-analysisSpontaneous breathing trialSystematic reviewWeaning

Identifiers

PMID28576127
PMCPMC5455092

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.