ArticleMolecular cell2017
The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis.
Article in Molecular cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67 citing papers in PubMed, 147 citations in OpenAlex.
- Brassinosteroids promote sugar synthesis by inhibiting BIN2 phosphorylation of phosphoenolpyruvate carboxykinase.Nature plants · 2026Article
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- Ubiquitination-Mediated Regulation of Brassinosteroid Signaling.Plants (Basel, Switzerland) · 2026Review
- Evaluation of the genes CYPEnvironmental science and pollution research international · 2026Article
- Brassinosteroids promote sugar synthesis by inhibiting BIN2 phosphorylation of phosphoenolpyruvate carboxykinase.bioRxiv : the preprint server for biology · 2025Article
- Natural variation in the GhTTL promoter modulates cotton fiber elongation through the GhTALE-GhTTL-GhBIN2 module.Plant communications · 2025Article
- Manipulating brassinosteroid signaling pathway to genetically improve horticultural plants.aBIOTECH · 2025Review
- Understanding the Brassinosteroid-Dependent Environmental Adaption in Brassicaceae Plants.Plants (Basel, Switzerland) · 2025Review
- Brassinosteroid Signaling Dynamics: Ubiquitination-Dependent Regulation of Core Signaling Components.International journal of molecular sciences · 2025Review
- FERONIA signaling maintains cell wall integrity during brassinosteroid-induced cell expansion in Arabidopsis.Molecular plant · 2025Article
- Differential Modulation of Brassinosteroid and Ethylene Signalling Systems by Native and Constitutively Active Forms of thePlants (Basel, Switzerland) · 2025Article
- Dressed Up to the Nines: The Interplay of Phytohormones Signaling and Redox Metabolism During Plant Response to Drought.Plants (Basel, Switzerland) · 2025Review
- Sex on Steroids: How Brassinosteroids Shape Reproductive Development in Flowering Plants.Plant & cell physiology · 2024Review
- Brassinosteroid biosynthesis and signaling: Conserved and diversified functions of core genes across multiple plant species.Plant communications · 2024Review
- Overexpression ofPlant direct · 2024Article
- Copine proteins are required for brassinosteroid signaling in maize and Arabidopsis.Nature communications · 2024Article
- OneFlowTraX: a user-friendly software for super-resolution analysis of single-molecule dynamics and nanoscale organization.Frontiers in plant science · 2024Article
- Article
- GmBES1-1 dampens the activity of GmNSP1/2 to mediate brassinosteroid inhibition of nodulation in soybean.Plant communications · 2023Article
- Influence of Exogenous 24-Epicasterone on the Hormonal Status of Soybean Plants.Plants (Basel, Switzerland) · 2023Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
The glycogen synthase kinase-3 (GSK3) family kinases are central cellular regulators highly conserved in all eukaryotes. In Arabidopsis, the GSK3-like kinase BIN2 phosphorylates a range of proteins to control broad developmental processes, and BIN2 is degraded through unknown mechanism upon receptor kinase-mediated brassinosteroid (BR) signaling. Here we identify KIB1 as an F-box E3 ubiquitin ligase that promotes the degradation of BIN2 while blocking its substrate access. Loss-of-function mutations of KIB1 and its homologs abolished BR-induced BIN2 degradation and caused severe BR-insensitive phenotypes. KIB1 directly interacted with BIN2 in a BR-dependent manner and promoted BIN2 ubiquitination in vitro. Expression of an F-box-truncated KIB1 caused BIN2 accumulation but dephosphorylation of its substrate BZR1 and activation of BR responses because KIB1 blocked BIN2 binding to BZR1. Our study demonstrates that KIB1 plays an essential role in BR signaling by inhibiting BIN2 through dual mechanisms of blocking substrate access and promoting degradation.
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