Evidence map›Paper›PMID 28575540›Full record

ArticleCPT: pharmacometrics & systems pharmacology2017

Optimizing Antipsychotic Patient Management Using Population Pharmacokinetic Models and Point-of-Care Testing.

B Green, J Korell, B Remmerie, A Savitz, A Vermeulen

Open access · goldAbstract readEditorial
In one paragraph

Article in CPT: pharmacometrics & systems pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

B GreenModel Answers Pty Ltd, Brisbane, Australia.
J KorellModel Answers Pty Ltd, Brisbane, Australia.
B RemmerieQuantitative Sciences, Janssen Research & Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium.
A SavitzNeurosciences, Janssen Research & Development, Titusville, New Jersey, USA.
A VermeulenQuantitative Sciences, Janssen Research & Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium.
IP Australia · AUJanssen (Belgium) · BEJanssen (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia is a common disease, characterized by progressive functional decline exacerbated by psychotic relapses that often result from a lack of full adherence to antipsychotic (APS) medication. Although atypical APS medications do not have clear therapeutic windows, as generally required for therapeutic drug monitoring (TDM), measuring APS plasma levels in the context of a population expected range at the point-of-care (POC) may provide valuable clinical insights for differentiating lack of efficacy from a lack of adherence to medication.

Indexed as

Antipsychotic AgentsHumansModels, BiologicalPoint-of-Care TestingSchizophreniaAntipsychotic Agents

Identifiers

PMID28575540
PMCPMC5613188
OpenAlexW2620906069

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.