ArticleSchizophrenia bulletin2018
Limbic Interference During Social Action Planning in Schizophrenia.
Article in Schizophrenia bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- The mirror mechanism in schizophrenia: A systematic review and qualitative meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Gesture deficits in psychosis and the combination of group psychotherapy and transcranial magnetic stimulation: A randomized clinical trial.Molecular psychiatry · 2025Trial
- Single Session Transcranial Magnetic Stimulation Ameliorates Hand Gesture Deficits in Schizophrenia.Schizophrenia bulletin · 2020Trial
- Aberrant gesture use in autism spectrum disorders is unrelated to motor abnormalities.European archives of psychiatry and clinical neuroscience · 2026Article
- Gesture Impairments in Schizophrenia: Distinct Roles of Negative Symptoms and Formal Thought Disorder.Schizophrenia bulletin · 2026Article
- Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study.Scientific reports · 2026Article
- Transdiagnostic associations between subjective gesture behaviour and objective performance in schizophrenia and depression.Translational psychiatry · 2026Article
- The application of amplitude of low-frequency fluctuations metrics in the diagnosis and prediction of treatment response as well as their associated genes and biological processes in patients with bipolar disorder.Translational psychiatry · 2025Article
- Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder.Schizophrenia (Heidelberg, Germany) · 2025Article
- I fear you're getting too close: neural correlates of personal space violation in paranoia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Abnormalities in cognitive-related functional connectivity can be used to identify patients with schizophrenia and individuals in clinical high-risk.BMC psychiatry · 2025Article
- Amygdala Function, Blood Flow, and Functional Connectivity in Nonclinical Schizotypy.Schizophrenia bulletin · 2025Article
- Aberrant preparation of hand movement in schizophrenia spectrum disorder: an fMRI study.Brain communications · 2025Article
- Functional Connectivity-Based Searchlight Multivariate Pattern Analysis for Discriminating Schizophrenia Patients and Predicting Clinical Variables.Schizophrenia bulletin · 2024Article
- Changes in responses of the amygdala and hippocampus during fear conditioning are associated with persecutory beliefs.Scientific reports · 2024Article
- Selective disrupted gray matter volume covariance of amygdala subregions in schizophrenia.Frontiers in psychiatry · 2024Article
- Resting-state perfusion in motor and fronto-limbic areas is linked to diminished expression of emotion and speech in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Gesticulation in individuals with at risk mental states for psychosis.Schizophrenia (Heidelberg, Germany) · 2023Article
- Frequency-Specific Analysis of the Dynamic Reconfiguration of the Brain in Patients with Schizophrenia.Brain sciences · 2022Article
- Using dynamic point light display stimuli to assess gesture deficits in schizophrenia.Schizophrenia research. Cognition · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is characterized by social interaction deficits contributing to poor functional outcome. Hand gesture use is particularly impaired, linked to frontal lobe dysfunction and frontal grey matter deficits. The functional neural correlates of impaired gesturing are currently unclear. We therefore investigated aberrant brain activity during impaired gesturing in schizophrenia. We included 22 patients with schizophrenia and 25 healthy control participants matched for age, gender, and education level. We obtained functional magnetic resonance imaging data using an event-related paradigm to assess brain activation during gesture planning and execution. Group differences in whole brain effects were calculated using factorial designs. Gesture ratings were performed by a single rater, blind to diagnoses and clinical presentation. During gesture planning and execution both groups activated brain areas of the praxis network. However, patients had reduced dorsolateral prefrontal cortex (DLPFC) and increased inferior parietal lobe (IPL) activity. Performance accuracy was associated with IPL activity in patients. Furthermore, patients activated temporal poles, amygdala and hippocampus during gesture planning, which was associated with delusion severity. Finally, patients demonstrated increased dorsomedial prefrontal cortex activity during planning of novel gestures. We demonstrate less prefrontal, but more IPL and limbic activity during gesturing in schizophrenia. IPL activity was associated with performance accuracy, whereas limbic activity was linked to delusion severity. These findings may reflect impaired social action planning and a limbic interference with gestures in schizophrenia contributing to poor gesture performance and consequently poor social functioning in schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.