ArticleMolecular biology and evolution2017
Intra and Interspecific Variations of Gene Expression Levels in Yeast Are Largely Neutral: (Nei Lecture, SMBE 2016, Gold Coast).
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Signatures of nonsense-mediated mRNA decay but no evidence for transcriptional adaptation associated with protein-truncating variants in wild yeast diploids.Molecular biology and evolution · 2026Article
- Repeatability of gene expression evolution in experimental environmental adaptation.Nature communications · 2026Article
- Host and venom evolution in parasitoid wasps: does independently adapting to the same host shape the evolution of the venom gland transcriptome?BMC biology · 2024Article
- The metabolic domestication syndrome of budding yeast.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Extensive Adaptive Variation in Gene Expression within and between Closely Related Horseshoe Bats (Chiroptera,Animals : an open access journal from MDPI · 2022Article
- Rapid Intraspecies Evolution of Fitness Effects of Yeast Genes.Genome biology and evolution · 2022Article
- Article
- Avoidance of protein unfolding constrains protein stability in long-term evolution.Biophysical journal · 2021Article
- Effective Population Size Predicts Local Rates but Not Local Mitigation of Read-through Errors.Molecular biology and evolution · 2021Article
- Perspectives on studying molecular adaptations of amphibians in the genomic era.Zoological research · 2020Review
- Gene expression of functionally-related genes coevolves across fungal species: detecting coevolution of gene expression using phylogenetic comparative methods.BMC genomics · 2020Article
- Parallel transcriptomic changes in the origins of divergent monogamous vertebrates?Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3' additional stop codons.PLoS genetics · 2019Article
- Evolution of substrate-specific gene expression and RNA editing in brown rot wood-decaying fungi.The ISME journal · 2019Article
- The Effects of Demography and Genetics on the Neutral Distribution of Quantitative Traits.Genetics · 2019Article
- Hybridization is a recurrent evolutionary stimulus in wild yeast speciation.Nature communications · 2019Article
- The Evolution of Gene Expression Underlying Vision Loss in Cave Animals.Molecular biology and evolution · 2018Article
- Neutral Theory and Phenotypic Evolution.Molecular biology and evolution · 2018Article
- Linkage mapping of yeast cross protection connects gene expression variation to a higher-order organismal trait.PLoS genetics · 2018Article
- Pervasive Correlated Evolution in Gene Expression Shapes Cell and Tissue Type Transcriptomes.Genome biology and evolution · 2018Article
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5 authors.
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Abstract
It is commonly, although not universally, accepted that most intra and interspecific genome sequence variations are more or less neutral, whereas a large fraction of organism-level phenotypic variations are adaptive. Gene expression levels are molecular phenotypes that bridge the gap between genotypes and corresponding organism-level phenotypes. Yet, it is unknown whether natural variations in gene expression levels are mostly neutral or adaptive. Here we address this fundamental question by genome-wide profiling and comparison of gene expression levels in nine yeast strains belonging to three closely related Saccharomyces species and originating from five different ecological environments. We find that the transcriptome-based clustering of the nine strains approximates the genome sequence-based phylogeny irrespective of their ecological environments. Remarkably, only ∼0.5% of genes exhibit similar expression levels among strains from a common ecological environment, no greater than that among strains with comparable phylogenetic relationships but different environments. These and other observations strongly suggest that most intra and interspecific variations in yeast gene expression levels result from the accumulation of random mutations rather than environmental adaptations. This finding has profound implications for understanding the driving force of gene expression evolution, genetic basis of phenotypic adaptation, and general role of stochasticity in evolution.
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