ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Should Controls With Respiratory Symptoms Be Excluded From Case-Control Studies of Pneumonia Etiology? Reflections From the PERCH Study.
Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 21 citations in OpenAlex.
- A case-control study of the causes of acute respiratory infection among hospitalized patients in Northeastern Laos.Scientific reports · 2022Trial
- Effects of Maternal Vitamin D Supplementation During Pregnancy and Lactation on Infant Acute Respiratory Infections: Follow-up of a Randomized Trial in Bangladesh.Journal of the Pediatric Infectious Diseases Society · 2021Trial
- Respiratory viruses associated with severe acute respiratory infection in children aged <5 years at a tertiary care hospital in Delhi, India during 2013-15.Journal of global health · 2024Article
- Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study.Scientific reports · 2023Article
- Aetiology of acute respiratory infection in preschool children requiring hospitalisation in Europe-results from the PED-MERMAIDS multicentre case-control study.BMJ open respiratory research · 2021Article
- Pneumococcal colonization prevalence and density among Thai children with severe pneumonia and community controls.PloS one · 2020Article
- Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review.PLoS neglected tropical diseases · 2019Article
- Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study.Lancet (London, England) · 2019Article
- Epidemiology of viral acute lower respiratory infections in a community-based cohort of rural north Indian children.Journal of global health · 2019Article
- Assessment of an Antibody-in-Lymphocyte Supernatant Assay for the Etiological Diagnosis of Pneumococcal Pneumonia in Children.Frontiers in cellular and infection microbiology · 2019Article
- Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2018Article
- Etiology of Childhood Pneumonia: What We Know, and What We Need to Know! : Based on 5th Dr. IC Verma Excellence Oration Award.Indian journal of pediatrics · 2018Review
- Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study.PloS one · 2018Article
- Addressing the Analytic Challenges of Cross-Sectional Pediatric Pneumonia Etiology Data.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Review
- Introduction to the Epidemiologic Considerations, Analytic Methods, and Foundational Results From the Pneumonia Etiology Research for Child Health Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Review
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20 authors at 10 institutions in 8 countries.
Funding
Abstract
Many pneumonia etiology case-control studies exclude controls with respiratory illness from enrollment or analyses. Herein we argue that selecting controls regardless of respiratory symptoms provides the least biased estimates of pneumonia etiology. We review 3 reasons investigators may choose to exclude controls with respiratory symptoms in light of epidemiologic principles of control selection and present data from the Pneumonia Etiology Research for Child Health (PERCH) study where relevant to assess their validity. We conclude that exclusion of controls with respiratory symptoms will result in biased estimates of etiology. Randomly selected community controls, with or without respiratory symptoms, as long as they do not meet the criteria for case-defining pneumonia, are most representative of the general population from which cases arose and the least subject to selection bias.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.