Evidence map›Paper›PMID 28575235›Full record

Trial reportEuropean heart journal2017

Remote management of heart failure using implantable electronic devices.

John M Morgan, Sue Kitt, Jas Gill, Janet M McComb, Ghulam Andre Ng, James Raftery, Paul Roderick, Alison Seed, Simon G Williams, Klaus K Witte and 3 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European heart journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  12. Comprehensive vs. standard remote monitoring of cardiac resynchronization devices in heart failure patients: results of the ECOST-CRT study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
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  14. Effect of remote monitoring on clinical outcomes in European heart failure patients with an implantable cardioverter-defibrillator: secondary results of the REMOTE-CIED randomized trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022
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68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

John M MorganFaculty of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK.
Sue KittWessex Cardiology Centre, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Jas GillDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK.
Janet M McCombDepartment of Cardiology, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne NE7 7DN, UK.
Ghulam Andre NgNIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
James RafteryFaculty of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK.
Paul RoderickFaculty of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK.
Alison SeedDepartment of Cardiology, Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool FY3 8NR, UK.
Simon G WilliamsDepartment of Cardiology, University Hospitals of South Manchester NHS Foundation Trust, Manchester M13 9WL, UK.
Klaus K WitteMultidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK.
David Jay WrightInstitute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool L14 3PE, UK.
Scott HarrisFaculty of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK.
Martin R CowieImperial College London (Royal Brompton Hospital), Dovehouse Street, London SW3 6LY, UK.

Funding

Department of Health NIHR-CS-012-032
6 · The paper itself

Abstract

aimsRemote management of heart failure using implantable electronic devices (REM-HF) aimed to assess the clinical and cost-effectiveness of remote monitoring (RM) of heart failure in patients with cardiac implanted electronic devices (CIEDs). METHODS AND

resultsBetween 29 September 2011 and 31 March 2014, we randomly assigned 1650 patients with heart failure and a CIED to active RM or usual care (UC). The active RM pathway included formalized remote follow-up protocols, and UC was standard practice in nine recruiting centres in England. The primary endpoint in the time to event analysis was the 1st event of death from any cause or unplanned hospitalization for cardiovascular reasons. Secondary endpoints included death from any cause, death from cardiovascular reasons, death from cardiovascular reasons and unplanned cardiovascular hospitalization, unplanned cardiovascular hospitalization, and unplanned hospitalization. REM-HF is registered with ISRCTN (96536028). The mean age of the population was 70 years (range 23-98); 86% were male. Patients were followed for a median of 2.8 years (range 0-4.3 years) completing on 31 January 2016. Patient adherence was high with a drop out of 4.3% over the course of the study. The incidence of the primary endpoint did not differ significantly between active RM and UC groups, which occurred in 42.4 and 40.8% of patients, respectively [hazard ratio 1.01; 95% confidence interval (CI) 0.87-1.18; P = 0.87]. There were no significant differences between the two groups with respect to any of the secondary endpoints or the time to the primary endpoint components.

conclusionAmong patients with heart failure and a CIED, RM using weekly downloads and a formalized follow up approach does not improve outcomes.

Indexed as

Defibrillators, ImplantableRemote ConsultationAdultAgedAged, 80 and overCardiac Resynchronization TherapyCardiac Resynchronization Therapy DevicesFemaleHeart FailureHumansMaleMiddle AgedMonitoring, AmbulatoryPatient ComplianceHeart failureImplantable devicesRemote monitoring

Identifiers

PMID28575235
PMCPMC5837548

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.