ArticlePloS one2017
Follistatin like-1 (Fstl1) is required for the normal formation of lung airway and vascular smooth muscle at birth.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Fstl1 determines luminal size of mouse trachea through negative regulation of BMP4 signaling.iScience · 2026Article
- Follistatin-like protein 1 (FSTL1) modulates bone remodeling and attenuates bone loss in a mouse model of postmenopausal osteoporosis.JBMR plus · 2026Article
- Follistatin like-1 (Adipocyte · 2024Article
- Article
- BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Follistatin-Like Proteins: Structure, Functions and Biomedical Importance.Biomedicines · 2021Review
- Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies.Development (Cambridge, England) · 2021Article
- FSTL1 aggravates cigarette smoke-induced airway inflammation and airway remodeling by regulating autophagy.BMC pulmonary medicine · 2021Article
- Regulation of Pulmonary Bacterial Immunity by Follistatin-Like Protein 1.Infection and immunity · 2020Article
- Secretome Analysis of Inductive Signals for BM-MSC Transdifferentiation into Salivary Gland Progenitors.International journal of molecular sciences · 2020Article
- FSTL1 enhances chemoresistance and maintains stemness in breast cancer cells via integrin β3/Wnt signaling under miR-137 regulation.Cancer biology & therapy · 2019Article
- Cell type specific expression of Follistatin-like 1 (Fstl1) in mouse embryonic lung development.Journal of molecular histology · 2018Article
- Effects of FSTL1 on the proliferation and motility of breast cancer cells and vascular endothelial cells.Thoracic cancer · 2017Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fstl1, a secreted protein of the BMP antagonist class, has been implicated in the regulation of lung development and alveolar maturation. Here we generated a Fstl1-lacZ reporter mouse line as well as a Fstl1 knockout allele. We localized Fstl1 transcript in lung smooth muscle cells and identified Fstl1 as essential regulator of lung smooth muscle formation. Deletion of Fstl1 in mice led to postnatal death as a result of respiratory failure due to multiple defects in lung development. Analysis of the mutant phenotype showed impaired airway smooth muscle (SM) manifested as smaller SM line in trachea and discontinued SM surrounding bronchi, which were associated with decreased transcriptional factors myocardin/serum response factor (SRF) and impaired differentiation of SM cells. Fstl1 knockout mice also displayed abnormal vasculature SM manifested as hyperplasia SM in pulmonary artery. This study indicates a pivotal role for Fstl1 in early stage of lung airway smooth muscle development.
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