ArticlePLoS computational biology2017
A motor unit-based model of muscle fatigue.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The trial behind it
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Who cites it
50 citing papers in PubMed, 149 citations in OpenAlex.
- Altered anabolic signalling and reduced stimulation of myofibrillar protein synthesis after feeding and resistance exercise in people with obesity.The Journal of physiology · 2018Trial
- Real-Time Physiological Fatigue Prediction for Human-Robot Collaborative Manufacturing Using Wearable Sensor Fusion and Hybrid Deep Learning: An In Silico Digital Twin Study.Sensors (Basel, Switzerland) · 2026Article
- The Influence of Dual Source Cerebellar Transcranial Direct Current Stimulation on Muscle Fatigue.Journal of functional morphology and kinesiology · 2026Article
- Shoulder Kinematic and Muscle Activity Compensations to Scapular Stabilizer Weakness: An Optimal Control Framework.Annals of biomedical engineering · 2026Article
- Model-based analysis of sEMG signals using Stockwell transform features under varied muscle fiber composition and conduction velocity.Medical & biological engineering & computing · 2025Article
- Matching dynamically varying forces with multi-motor-unit muscle models: a simulation study.Royal Society open science · 2025Article
- The effects of low vs. high rating of perceived exertion clamp exercise on performance, neuromuscular, and muscle oxygen saturation responses in females.European journal of applied physiology · 2025Article
- Cloud and IoT based smart agent-driven simulation of human gait for detecting muscles disorder.Heliyon · 2025Article
- Biomechanical differences in lower limb movements during lifting tasks before and after fatigue.Frontiers in bioengineering and biotechnology · 2025Article
- Acute effects of different physical activity on executive function and regulation role of beta oscillation in sedentary youth frontal region.Scientific reports · 2024Article
- Greater Neuromuscular and Perceptual Fatigue after Low versus High Loads in the Bench Press: A Preliminary Study Applying Frequentist and Bayesian Group Analyses with Subject-by-Subject Case Series Reports.Journal of functional morphology and kinesiology · 2024Article
- No sex differences in time-to-task failure and neuromuscular patterns of response during submaximal, bilateral, isometric leg extensions.European journal of applied physiology · 2024Article
- Analysis of Wavelet Coherence in Calf Agonist-Antagonist Muscles during Dynamic Fatigue.Life (Basel, Switzerland) · 2024Article
- Focal muscle vibration and action observation: a combined approach for muscle strengthening.European journal of translational myology · 2024Article
- Onion skin is not a universal firing pattern for spinal motoneurons: simulation study.Journal of neurophysiology · 2024Article
- Force and Neuromuscular Responses During a Handgrip Hold to Failure Anchored to a Moderate Perceptual Intensity in Males.Journal of musculoskeletal & neuronal interactions · 2024Article
- Disuse-Induced Muscle Fatigue: Facts and Assumptions.International journal of molecular sciences · 2024Review
- Minimization of metabolic cost of transport predicts changes in gait mechanics over a range of ankle-foot orthosis stiffnesses in individuals with bilateral plantar flexor weakness.Frontiers in bioengineering and biotechnology · 2024Article
- From Simulation to Reality: Predicting Torque With Fatigue Onset via Transfer Learning.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2024Article
- Oh, My Quad: A Clinical Commentary And Evidence-Based Framework for the Rehabilitation of Quadriceps Size and Strength after Anterior Cruciate Ligament Reconstruction.International journal of sports physical therapy · 2024Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Muscle fatigue is a temporary decline in the force and power capacity of skeletal muscle resulting from muscle activity. Because control of muscle is realized at the level of the motor unit (MU), it seems important to consider the physiological properties of motor units when attempting to understand and predict muscle fatigue. Therefore, we developed a phenomenological model of motor unit fatigue as a tractable means to predict muscle fatigue for a variety of tasks and to illustrate the individual contractile responses of MUs whose collective action determines the trajectory of changes in muscle force capacity during prolonged activity. An existing MU population model was used to simulate MU firing rates and isometric muscle forces and, to that model, we added fatigue-related changes in MU force, contraction time, and firing rate associated with sustained voluntary contractions. The model accurately estimated endurance times for sustained isometric contractions across a wide range of target levels. In addition, simulations were run for situations that have little experimental precedent to demonstrate the potential utility of the model to predict motor unit fatigue for more complicated, real-world applications. Moreover, the model provided insight into the complex orchestration of MU force contributions during fatigue, that would be unattainable with current experimental approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.