Evidence map›Paper›PMID 28574979›Full record

Observational studyPediatric research2017

Antenatal corticosteroids and cardiometabolic outcomes in adolescents born with very low birth weight.

Lisa K Washburn, Patricia A Nixon, Beverly M Snively, Gregory B Russell, Hossam A Shaltout, Andrew M South, T Michael O'Shea

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Association of antenatal corticosteroids with kidney function in adolescents born preterm with very low birth weight.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Article
  5. Observational
  6. Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep.American journal of obstetrics and gynecology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Lisa K WashburnDepartment of Pediatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Patricia A NixonDepartment of Pediatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Beverly M SnivelyDivision of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University, Winston-Salem, North Carolina.
Gregory B RussellDivision of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University, Winston-Salem, North Carolina.
Hossam A ShaltoutHypertension and Vascular Research, Cardiovascular Sciences Center, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Andrew M SouthDepartment of Pediatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina.
T Michael O'SheaDepartment of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Wake Forest University · USUniversity of North Carolina at Chapel Hill · US

Funding

WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KOCH, KENNETH L · 1992 to 2010
$35.2M
The Impact of Antenatal Steroid Exposure on the Intrarenal Renin-Angiotensin SystP01HD047584 · NICHD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ROSE, JAMES C. · 2005 to 2016
$13.0M
TRAINING PROGRAM IN ACADEMIC NEPHROLOGYT32DK007357 · NIDDK · STANFORD UNIVERSITY · PI CHERTOW, GLENN MATTHEW · 1986 to 2022
$4.8M
NCRR NIH HHS M01 RR007122NICHD NIH HHS P01 HD047584NIDDK NIH HHS T32 DK007357
6 · The paper itself

Abstract

BackgroundExposure to antenatal corticosteroids (ANCS) is associated with adverse cardiometabolic outcomes in animal models; however, long-term outcomes in clinical studies are not well characterized. We hypothesized that exposure to ANCS would be associated with markers of increased cardiometabolic risk in adolescents born with very low birth weight (VLBW).MethodsIn an observational cohort of 186 14-year-old adolescents born with VLBW, we measured resting blood pressure (BP), BP response to cold, ambulatory BP, and anthropometrics; performed dual-energy X-ray absorptiometry; and analyzed blood samples for uric acid, cholesterol, glycated hemoglobin, and high-sensitivity C-reactive protein. Multivariate analyses were used to evaluate associations with ANCS, adjusting for race, sex, and maternal hypertensive pregnancy.ResultsThere were no ANCS group differences in BP measures or blood biomarkers. Compared with adolescents unexposed to ANCS, those exposed to ANCS were taller (exposed-unexposed mean difference 3.1 cm (95% confidence interval (CI) 0.7, 5.5)) and had decreased waist-to-height ratio (exposed-unexposed mean difference -0.03 (95% CI -0.058, -0.002)). Males exposed to ANCS had lower total cholesterol (exposed-unexposed mean difference -0.54 mmol/l (95%CI -0.83, -0.06)).ConclusionAmong adolescents born with VLBW, ANCS exposure was not associated with markers of increased cardiometabolic risk.

Indexed as

Infant, Very Low Birth WeightAdolescentAdrenal Cortex HormonesBiomarkersBirth WeightBlood PressureBody CompositionCardiovascular DiseasesCholesterolC-Reactive ProteinFemaleGlycated HemoglobinHumansInfant, NewbornLeast-Squares AnalysisLinear ModelsAdrenal Cortex HormonesBiomarkersCholesterolC-Reactive ProteinGlycated Hemoglobinhemoglobin A1c protein, humanUric Acid

Identifiers

PMID28574979
PMCPMC5599338
OpenAlexW2621095629

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.