ArticleOncotarget2017
Associations between APOE genotype and cerebral small-vessel disease: a longitudinal study.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- The etiology and evolution of magnetic resonance imaging-visible perivascular spaces: Systematic review and meta-analysis.Frontiers in neuroscience · 2023Pooled it
- Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition.GeroScience · 2026Article
- Correlations between white matter hyperintensities, magnetic resonance imaging findings, and cognition in the oldest old: a multimodal cross-sectional study.GeroScience · 2026Article
- Neurite orientation dispersion and density imaging identifies microstructural alterations in patients with cerebral microbleeds and correlations with cognitive impairment.BMC neurology · 2026Observational
- Midlife Retinal Microvascular Signs and Late-Life Neuroimaging Features of Cerebral Small Vessel Disease in the ARIC Study.Neurology · 2025Article
- Body Circumference and Cognitive Function: Role of Apolipoprotein E ε4 in the Elderly.International journal of molecular sciences · 2025Article
- Prediction of white matter hyperintensities evolution one-year post-stroke from a single-point brain MRI and stroke lesions information.Scientific reports · 2025Article
- Elevated monocyte-to-high-density lipoprotein ratio is associated with increased risk of cognitive impairment and severe cerebral small vessel disease burden.Frontiers in aging neuroscience · 2025Article
- Mirodenafil improves cognitive function by reducing microglial activation and blood-brain barrier permeability in ApoE4 KI mice.Frontiers in aging neuroscience · 2025Article
- Perivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study.Alzheimer's research & therapy · 2024Observational
- Brain structure, amyloid, and behavioral features for predicting clinical progression in subjective cognitive decline.Human brain mapping · 2024Article
- Perivascular space burden interacts with APOE-ε4 status on cognition in older adults.Neurobiology of aging · 2024Article
- The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer's disease continuum participants.Alzheimer's research & therapy · 2024Article
- White matter hyperintensity longitudinal morphometric analysis in association with Alzheimer disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Distinct cerebral small vessel disease impairment in early- and late-onset Alzheimer's disease.Annals of clinical and translational neurology · 2023Article
- Observational
- Association of Apolipoprotein E ɛ4 Allele with Enlarged Perivascular Spaces.Annals of neurology · 2022Article
- Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain.Neurology · 2022Article
- Enlarged Perivascular Spaces Are Negatively Associated With Montreal Cognitive Assessment Scores in Older Adults.Frontiers in neurology · 2022Article
- Biomarkers involved in the pathogenesis of cerebral small-vessel disease.Frontiers in neurology · 2022Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIt remains unclear if and how the interactions between APOE genotypes and cerebral small-vessel diseases (CSVD) lead to cognitive decline in the long term. Based on ADNI cohort, this longitudinal study aimed to clarify the potential relationship among APOE genotype, CSVD and cognition by integrating multi-level data.
methodThere were 135 healthy elderly (including ε2, ε4 allele carriers and ε3 homozygotes) who had completed two years' follow-up. MRI markers of CSVD, including white matter hyperintensities (WMH), dilated perivascular space (dPVS), microbleeds and lacune, were assessed. Besides, neuropathological factors including Alzheimer's disease-related pathology measured by CSF and PiB-PET were assessed. Repeated measurements ANOVAs were performed to test impact of different APOE genotypes on CSVD.
resultsWe found that APOE ε4 carriers had significantly more frontal WMH burden and basal ganglia dPVS at baseline and faster progression of frontal WMH burden during follow-up. Furthermore, our results showed that APOE ε4 carriers had significantly decreased Aβ1-42 level, and its level was negatively related with baseline and progressive total WMH burden. Then, general linear modals indicated interaction between basal frontal WMH burden and ε4 allele was related with declining trend of cognition.
conclusionOur findings suggested APOE ε4 allele was associated with increased Aβ deposition, which may lead to the formation and progression of WMH, especially in frontal lobe. Besides, interaction between the increased frontal WMH burden and ε4 allele can exert long-term detrimental effects on individual's trajectory of cognition.
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