ReviewChemical research in toxicology2017
Ozone Exposure, Cardiopulmonary Health, and Obesity: A Substantive Review.
Review in Chemical research in toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Exposure to PMInternational journal of environmental research and public health · 2021Pooled it
- Negative and Nonlinear Association Between Particulate Matter and Cardiorespiratory Fitness Among Children and Adolescents: The Mediating Effect of Adiposity.Journal of the American Heart Association · 2026Article
- Ozone exposure and cardiovascular disease: A narrative review of epidemiology evidence and underlying mechanisms.Fundamental research · 2025Review
- Exposure to air pollution is associated with adipokines in midlife women: The Study of Women's Health Across the Nation.The Science of the total environment · 2024Article
- Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus Are Sex-Specific.International journal of molecular sciences · 2023Article
- Target the neglected VOCs emission from iron and steel industry in China for air quality improvement.Frontiers of environmental science & engineering · 2023Article
- Chemical Characteristics and Source-Specific Health Risks of the Volatile Organic Compounds in Urban Nanjing, China.Toxics · 2022Article
- SARS-CoV2 neutralizing activity of ozone on porous and non-porous materials.New biotechnology · 2022Article
- Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2.Scientific reports · 2022Article
- The effects of ozone exposure and sedentary lifestyle on neuronal microglia and mitochondrial bioenergetics of female Long-Evans rats.Toxicology and applied pharmacology · 2020Article
- Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium.Chemical research in toxicology · 2019Article
- Ozone Pollution: A Major Health Hazard Worldwide.Frontiers in immunology · 2019Review
- Through the Looking Glass:Applied in vitro toxicology · 2018Review
- Examining Joint Effects of Air Pollution Exposure and Social Determinants of Health in Defining "At-Risk" Populations Under the Clean Air Act: Susceptibility of Pregnant Women to Hypertensive Disorders of Pregnancy.World medical & health policy · 2018Article
- Assessing health risks from multiple environmental stressors: Moving from G×E to I×E.Mutation research. Reviews in mutation researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
From 1999-2014, obesity prevalence increased among adults and youth. Obese individuals may be uniquely susceptible to the proinflammatory effects of ozone because obese humans and animals have been shown to experience a greater decline in lung function than normal-weight subjects. Obesity is independently associated with limitations in lung mechanics with increased ozone dose. However, few epidemiologic studies have examined the interaction between excess weight and ozone exposure among adults. Using PubMed keyword searches and reference lists, we reviewed epidemiologic evidence to identify potential response-modifying factors and determine if obese or overweight adults are at increased risk of ozone-related health effects. We initially identified 170 studies, of which seven studies met the criteria of examining the interaction of excess weight and ozone exposure on cardiopulmonary outcomes in adults, including four short-term ozone exposure studies in controlled laboratory settings and three community epidemiologic studies. In the studies identified, obesity was associated with decreased lung function and increased inflammatory mediators. Results were inconclusive about the effect modification when data were stratified by sex. Obese and overweight populations should be considered as candidate at-risk groups for epidemiologic studies of cardiopulmonary health related to air pollution exposures. Air pollution is a modifiable risk factor that may decrease lung function among obese individuals with implications for environmental and occupational health policy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.