VEGF-A

Megan Stevens, Christopher R Neal, Andrew H J Salmon, David O Bates, Steven J Harper, Sebastian Oltean

Open access · hybridAbstract read

In one paragraph

Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it

0cells of the map it votes in

11citing papers in PubMed

1.9field-weighted citation impact, top 15% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease.American journal of physiology. Renal physiology · 2023
Review
The role of cellular crosstalk in the progression of diabetic nephropathy.Frontiers in endocrinology · 2023
Review
Expression and possible role of Smad3 in postnecrotizing enterocolitis stricture.World journal of pediatric surgery · 2022
Article
The VEGF-A exon 8 splicing-sensitive fluorescent reporter mouse is a novel tool to assess the effects of splicing regulatory compoundsRNA biology · 2019
Article
Modulation of Receptor Tyrosine Kinase Activity through Alternative Splicing of Ligands and Receptors in the VEGF-A/VEGFR Axis.Cells · 2019
Review
The natural drug DIAVIT is protective in a type II mouse model of diabetic nephropathy.PloS one · 2019
Article
Assessment of Kidney Function in Mouse Models of Glomerular Disease.Journal of visualized experiments : JoVE · 2018
Article
Endogenous Antiangiogenic Factors in Chronic Kidney Disease: Potential Biomarkers of Progression.International journal of molecular sciences · 2018
Review
Modulation of VEGF-A Alternative Splicing as a Novel Treatment in Chronic Kidney Disease.Genes · 2018
Review
Vascular Endothelial Growth Factor-A165b Restores Normal Glomerular Water Permeability in a Diphtheria-Toxin Mouse Model of Glomerular Injury.Nephron · 2018
Article
Beneficial or deleterious effects of vascular endothelial growth factor may depend on the isoform involved.The Journal of physiology · 2017
Article

4 · The record

Corrections and comments

Commented on by
Beneficial or deleterious effects of vascular endothelial growth factor may depend on the isoform involved.2017

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Megan StevensSchool of Physiology, Pharmacology and Neurosciences, University of Bristol, UK.ORCID 0000-0002-9662-3741

Christopher R NealBristol Renal, School of Clinical Sciences, University of Bristol, Bristol, UK.

Andrew H J SalmonSchool of Physiology, Pharmacology and Neurosciences, University of Bristol, UK.ORCID 0000-0002-0409-5348

David O BatesCancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0003-4850-2360

Steven J HarperSchool of Physiology, Pharmacology and Neurosciences, University of Bristol, UK.

Sebastian OlteanSchool of Physiology, Pharmacology and Neurosciences, University of Bristol, UK.ORCID 0000-0001-7890-8439

At Bristol · GBUniversity of Exeter · GBUniversity of Nottingham · GB

Funding

British Heart Foundation PG/15/53/31371Medical Research Council G0802829Medical Research Council G1002073

6 · The paper itself

Abstract

key pointsProgressive depletion of all vascular endothelial growth factor A (VEGF-A) splice isoforms from the kidney results in proteinuria and increased glomerular water permeability, which are both rescued by over-expression of VEGF-A ABSTRACT: Chronic kidney disease is strongly associated with a decrease in the expression of vascular endothelial growth factor A (VEGF-A). However, little is known about the contribution of VEGF-A splice isoforms to kidney physiology and pathology. Previous studies suggest that the splice isoform VEGF-A

Indexed as

AnimalsCell LineHumansKidneyMicePlatelet Endothelial Cell Adhesion Molecule-1PodocytesProtein IsoformsProteinuriaReceptors, Vascular Endothelial Growth FactorSrc Homology 2 Domain-Containing, Transforming Protein 1Vascular Endothelial Growth Factor APlatelet Endothelial Cell Adhesion Molecule-1Protein IsoformsReceptors, Vascular Endothelial Growth FactorShc1 protein, mouseSrc Homology 2 Domain-Containing, Transforming Protein 1Vascular Endothelial Growth Factor Aalternative splicingreno-protectionvascular endothelial growth factor

Identifiers

PMID28574576

DOI10.1113/JP274481

PMCPMC5621502

OpenAlexW2620869447

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.