Evidence map›Paper›PMID 28574153›Full record

Trial reportDiabetic medicine : a journal of the British Diabetic Association2017

Effects of dietary carbohydrate on 1,5-anhydroglucitol in a population without diabetes: results from the OmniCarb trial.

S P Juraschek, E R Miller, L J Appel, R H Christenson, F M Sacks, E Selvin

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetic medicine : a journal of the British Diabetic Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00051350 (Macronutrients and Cardiovascular Risk), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00051350 nacompletednot on this map

Macronutrients and Cardiovascular Risk

TypeinterventionalSponsorJohns Hopkins UniversityRan2002 to 2008Enrolled164ConditionsCardiovascular Diseases, Heart Diseases, Atherosclerosis, HypertensionArmsCARB
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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  14. An Update on Measures of Preoperative Glycemic Control.Plastic and reconstructive surgery. Global open · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

S P JuraschekJohns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD.ORCID 0000-0003-4168-2696
E R MillerJohns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD.
L J AppelJohns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD.
R H ChristensonUniversity of Maryland School of Medicine.
F M SacksHarvard T.H. Chan School of Public Health, Harvard Medical School, Brigham & Women's Hospital, Boston, MA, USA.
E SelvinJohns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD.
Johns Hopkins University · USBrigham and Women's Hospital · USUniversity of Maryland, Baltimore · US

Funding

Carbohydrate: Amount and Type Affecting Risk for CVD and DiabetesR01HL084568 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SACKS, FRANK M · 2007 to 2011
$10.2M
RENAL DISEASE EPIDEMIOLOGY TRAINING GRANTT32DK007732 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CREWS, DEIDRA CANDICE · 1995 to 2024
$7.7M
Research and Mentoring in the Clinical Epidemiology of Type 2 DiabetesK24DK106414 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2015 to 2019
$654k
Dietary carbohydrate & glycemic index effects on oxidation & inflammationR01HL095448 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MILLER, EDGAR RAYMOND · 2009 to 2012
$625k
NHLBI NIH HHS R01 HL084568NHLBI NIH HHS R01 HL095448NIDDK NIH HHS K24 DK106414NIDDK NIH HHS T32 DK007732
6 · The paper itself

Abstract

aimsTo determine the effects of dietary changes in amount and type of carbohydrate on 1,5-anhydroglucitol levels.

methodsWe conducted an ancillary study to a completed, randomized clinical trial in overweight and obese adults without diabetes (N=159). Using a crossover design, participants were fed each one of four diets in turn for 5 weeks, with 2-week washout periods inbetween. The four diets were: high glycaemic index (≥65) with high proportion of carbohydrate (58% kcal) (GC); low glycaemic index (GI≤45) with low proportion of carbohydrate (40% kcal) (gc); low glycaemic index with high proportion of carbohydrate (gC); and high glycaemic index with low proportion of carbohydrate (Gc). Plasma 1,5-anhydroglucitol levels were measured at baseline and after each feeding period.

resultsAt baseline, participants had a mean age of 53 years (53% women, 52% non-Hispanic black, 50% obese). Their mean fasting glucose and 1,5-anhydroglucitol levels were 97 mg/dl (5.4 mmol/l) and 18.6 μg/mL (113.3 μmol/l), respectively. Compared with baseline, each of the four diets reduced 1,5-anhydroglucitol by a range of -2.4 to -3.7 μg/mL (-14.6 to -22.5 μmol/l); all P <0.001). Reducing either glycaemic index or proportion of carbohydrate lowered 1,5-anhydroglucitol levels. These effects were additive, such that reducing both glycaemic index and proportion of carbohydrates decreased 1,5-anhydroglucitol by -1.31 μg/mL [95% CI: -1.63, -0.99; P<0.001 or -8.0 (-9.9, -6.0) μmol/l]. Furthermore, these effects were confirmed in a subgroup of participants with 12-h glucose monitoring and no documented hyperglycaemia (fasting glucose <160 mg/dl or 8.9 mmol/l).

conclusionsBoth type and amount of dietary carbohydrate affect 1,5-anhydroglucitol plasma concentrations in adults without diabetes. This finding contradicts the long-standing notion that 1,5-anhydroglucitol remains at constant concentrations in the blood in the absence of hyperglycaemic excursions. (Clinical trials registry number: NCT00051350).

Indexed as

AdultBlood GlucoseCross-Over StudiesDeoxyglucoseDietary CarbohydratesFemaleGlycemic IndexHumansHyperglycemiaMaleMiddle AgedObesityOverweight1,5-anhydroglucitolBlood GlucoseDeoxyglucoseDietary Carbohydrates

Identifiers

PMID28574153
PMCPMC5603394
OpenAlexW2621237851

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.