ArticleThe International journal of artificial organs2017
Continuous Renal Replacement Therapy: Forty-year Anniversary.
Article in The International journal of artificial organs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Lower versus standard dose-intensity continuous renal replacement therapy: a systematic review and meta-analysis.Critical care (London, England) · 2026Pooled it
- Effect of High-Volume Hemofiltration in Critically Ill Patients: A Systematic Review and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019Pooled it
- Early application of continuous high-volume haemofiltration can reduce sepsis and improve the prognosis of patients with severe burns.Critical care (London, England) · 2018Trial
- Innovation, Technology, and Telemedicine in Critical Care.Critical care clinics · 2026Review
- Lower versus standard dose-intensity continuous renal replacement therapy: a protocol for a systematic review and meta-analysis.BMJ open · 2026Article
- Effluent-Dose Response of Continuous Haemofiltration Integrated into Veno-Venous ECMO for Septic Shock: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2025Article
- Extracorporeal organ support for critically ill patients: Overcoming the past, achieving the maximum at present, and redefining the future.World journal of critical care medicine · 2024Article
- Development of a new miniaturized system for ultrafiltration.Heart failure reviews · 2024Review
- Article
- 21st century critical care medicine: An overview.World journal of critical care medicine · 2024Review
- [Application effects of bundle nursing of citric acid extracorporeal anticoagulation on continuous renal replacement therapy of severe burn patients].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- [Innovations in peritoneal dialysis].Der nephrologe · 2022Review
- Continuous Renal Replacement Therapy in the Critically Ill Patient: From Garage Technology to Artificial Intelligence.Journal of clinical medicine · 2021Review
- The prognosis and risk factors for acute kidney injury in high-risk patients after surgery for type A aortic dissection in the ICU.Journal of thoracic disease · 2021Article
- Review of acute kidney injury and continuous renal replacement therapy in pediatric extracorporeal membrane oxygenation.Indian journal of thoracic and cardiovascular surgery · 2021Review
- Article
- Acute Peritoneal Dialysis With Percutaneous Catheter Insertion for COVID-19-Associated Acute Kidney Injury in Intensive Care: Experience From a UK Tertiary Center.Kidney international reports · 2021Article
- Continuous Renal Replacement Therapy (CRRT) for Nonrenal Indications among Critically Ill Children with Malignancy.Case reports in pediatrics · 2021Article
- Effect of continuous renal replacement therapy adjuvant to broad-spectrum enzyme inhibitors on the efficacy and inflammatory cytokines in patients with severe acute pancreatitis.American journal of translational research · 2021Article
- Prescribing Continuous Kidney Replacement Therapy in Acute Kidney Injury: A Narrative Review.Kidney medicineReview
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 1977 Peter Kramer performed the first CAVH (continuous arteriovenous hemofiltration) treatment in Gottingen, Germany. CAVH soon became a reliable alternative to hemo- or peritoneal dialysis in critically ill patients. The limitations of CAVH spurred new research and the discovery of new treatments such as CVVH and CVVHD (continuous veno-venous hemofiltration and continuous veno-venous hemodialysis). The alliance with industry led to development of new specialized equipment with improved accuracy and performance in delivering continuous renal replacement therapies (CRRTs). Machines and filters have progressively undergone a series of technological steps, reaching a high level of sophistication. The evolution of technology has continued, leading to the development and clinical application of new membranes, new techniques and new treatment modalities. With the progress of technology, the entire field of critical care nephrology moved forward, expanding the areas of application of extracorporeal therapies to cardiac, liver and pulmonary support. A great deal of research made extracorporeal therapies an interesting option for the treatment of sepsis and intoxication and the additional use of sorbents was explored. With the progress in understanding the pathophysiology of acute kidney injury (AKI), new guidelines were developed, driving indications, modalities of prescription, monitoring techniques and quality assurance programs. Information technology and precision medicine have recently contributed to further evolution of CRRT, with the possibility of collecting data in large databases and evaluating policies and practice patterns. This is likely to ultimately result in improved patient care. CRRTs are 40 years old today, but they are still young and full of potential for further evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.