Evidence map›Paper›PMID 28574067›Full record

ArticleOrganic & biomolecular chemistry2017

Multi-responsive polypeptide hydrogels derived from N-carboxyanhydride terpolymerizations for delivery of nonsteroidal anti-inflammatory drugs.

Jingwei Fan, Richen Li, Hai Wang, Xun He, Tan P Nguyen, Rachel A Letteri, Jiong Zou, Karen L Wooley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Functional drug-delivery hydrogels for oral and maxillofacial wound healing.Frontiers in bioengineering and biotechnology · 2023
    Review
  6. Article
  7. Review
  8. Review
  9. Multicomponent peptide assemblies.Chemical Society reviews · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jingwei FanDepartments of Chemistry, Chemical Engineering, Materials Science and Engineering, and Laboratory for Synthetic-Biologic Interactions, Taxes A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX 77842, USA. wooley@chem.tamu.edu.
Richen LiDepartments of Chemistry, Chemical Engineering, Materials Science and Engineering, and Laboratory for Synthetic-Biologic Interactions, Taxes A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX 77842, USA. wooley@chem.tamu.edu.
Hai WangDepartments of Chemistry, Chemical Engineering, Materials Science and Engineering, and Laboratory for Synthetic-Biologic Interactions, Taxes A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX 77842, USA. wooley@chem.tamu.edu.
Xun HeDepartments of Chemistry, Chemical Engineering, Materials Science and Engineering, and Laboratory for Synthetic-Biologic Interactions, Taxes A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX 77842, USA. wooley@chem.tamu.edu.
Tan P NguyenDepartments of Chemistry, Chemical Engineering, Materials Science and Engineering, and Laboratory for Synthetic-Biologic Interactions, Taxes A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX 77842, USA. wooley@chem.tamu.edu.
Rachel A LetteriDepartments of Chemistry, Chemical Engineering, Materials Science and Engineering, and Laboratory for Synthetic-Biologic Interactions, Taxes A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX 77842, USA. wooley@chem.tamu.edu.
Jiong ZouDepartments of Chemistry, Chemical Engineering, Materials Science and Engineering, and Laboratory for Synthetic-Biologic Interactions, Taxes A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX 77842, USA. wooley@chem.tamu.edu.
Karen L WooleyDepartments of Chemistry, Chemical Engineering, Materials Science and Engineering, and Laboratory for Synthetic-Biologic Interactions, Taxes A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX 77842, USA. wooley@chem.tamu.edu.ORCID http://orcid.org/0000-0003-4086-384X

Funding

NHLBI NIH HHS HHSN268201000046C
6 · The paper itself

Abstract

A polypeptide-based hydrogel system, when prepared from a diblock polymer with a ternary copolypeptide as one block, exhibited thermo-, mechano- and enzyme-responsive properties, which enabled the encapsulation of naproxen (Npx) during the sol-gel transition and its release in the gel state. Statistical terpolymerizations of l-alanine (Ala), glycine (Gly) and l-isoleucine (Ile) NCAs at a 1 : 1 : 1 feed ratio initiated by monomethoxy monoamino-terminated poly(ethylene glycol) afforded a series of methoxy poly(ethylene glycol)-block-poly(l-alanine-co-glycine-co-l-isoleucine) (mPEG-b-P(A-G-I)) block polymers. β-Sheets were the dominant secondary structures within the polypeptide segments, which facilitated a heat-induced sol-to-gel transition, resulting from the supramolecular assembly of β-sheets into nanofibrils. Deconstruction of the three-dimensional networks by mechanical force (sonication) triggered the reverse gel-to-sol transition. Certain enzymes could accelerate the breakdown of the hydrogel, as determined by in vitro gel weight loss profiles. The hydrogels were able to encapsulate and release Npx over 6 days, demonstrating the potential application of these polypeptide hydrogels as an injectable local delivery system for small molecule drugs.

Indexed as

Drug Delivery SystemsAnhydridesAnti-Inflammatory Agents, Non-SteroidalHydrogelsMolecular StructurePeptidesPolymerizationAnhydridesAnti-Inflammatory Agents, Non-SteroidalHydrogelsPeptides

Identifiers

PMID28574067
PMCPMC5551480

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.