Evidence map›Paper›PMID 28574063›Full record

ArticleMcGill Science undergraduate research journal : MSURJ2015

Preschool children without 7-repeat DRD4 gene more likely to develop disorganized attachment style.

Justin Graffi, Ellen Moss, Alexia Jolicoeur-Martineau, Gal Moss, Vanessa Lecompte, Katherine Pascuzzo, Vanessa Babineau, Cathryn Gordon-Green, Viara R Mileva-Seitz, Klaus Minde and 7 more

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in McGill Science undergraduate research journal : MSURJ, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03434457 (Maternal Adversity, Vulnerability and Neurodevelopment), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03434457 completednot on this map

Maternal Adversity, Vulnerability and Neurodevelopment

TypeobservationalSponsorDouglas Mental Health University InstituteRan2003 to 2017Enrolled630ConditionsMental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development, Infant Behavior
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 2 countries.

Justin GraffiMcGill University, Montreal.
Ellen MossUniversity de Quebec à Montréal, Montreal.
Alexia Jolicoeur-MartineauMcGill University, Montreal.
Gal MossHebrew University, Jerusalem.
Vanessa LecompteUniversity de Quebec à Montréal, Montreal.
Katherine PascuzzoMcGill University, Montreal.
Vanessa BabineauMcGill University, Montreal.
Cathryn Gordon-GreenMcGill University, Montreal.
Viara R Mileva-SeitzLeidon University, Netherlands.
Klaus MindeMcGill University, Montreal.
Roberto SassiSt-Joseph's Healthcare, Hamilton.
Normand CarreyDalhousie University, Halifax.
James L KennedyCentre for Addiction and Mental Health, Toronto.
Helene GaudreauLudmer Centre for Neuroinformatics and Mental Health and, Douglas Mental Health University Institute, Montreal.
Robert LevitanCentre for Addiction and Mental Health, Toronto.
Michael MeaneyMcGill University, Montreal.
Ashley WazanaMcGill University, Montreal.
McGill University · CACentre for Addiction and Mental Health · CADouglas Mental Health University Institute · CAUniversité du Québec à Montréal · CADalhousie University · CAHebrew University of Jerusalem · ILJewish General Hospital · CAMontreal General Hospital · CASt. Joseph’s Healthcare Hamilton · CA

Funding

CIHR 111251-1
6 · The paper itself

Abstract

backgroundThe current paper aimed to explore the effects of birth weight and the 7-repeat allele in Exon III of the dopamine D4 receptor (DRD4) gene on the development of disorganized attachment, a potential endophenotype of depression. Infants born with low birth weight have been shown to be at higher risk for later neurological impairments, psychological disorders or behavioural problems. The DRD4 gene is critical for the cognitive and emotional processes that are sub-served by neural circuits in the prefrontal cortex. This paper examined the main effect of birth weight and DRD4 on the development of disorganized attachment.

methodsData was used from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) project. The sample consisted of 251 mother-child dyads with complete data. Attachment style was assessed using the modified separation-reunion procedure.

resultsThere was no main effect for birth weight on disorganized attachment, (b = -0.001, LIMITATIONS: Compared to studies of similar design, the sample size in this study was relatively small. Additionally, a significant number of subjects did not have complete data.

conclusionsChildren without the DRD4 7-repeat allele were more likely to have disorganized attachment than children with the DRD4 7-repeat allele. This indicates that the 7-repeate allele of the DRD4 gene may actually serve as a protective factor against disorganized attachment.

Indexed as

depressiondifferential susceptibilitydisorganized attachmentDRD4endophenotypelow birthweight

Identifiers

PMID28574063
PMCPMC5447455
OpenAlexW2971793108

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.