ArticleIndian journal of ophthalmology2017
Allergen-specific exposure associated with high immunoglobulin E and eye rubbing predisposes to progression of keratoconus.
Article in Indian journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The application of artificial intelligence-based algorithms in predicting the progression of keratoconus: a systematic review.International ophthalmology · 2025Pooled it
- Allergen skin test in children with vernal kerato conjunctivitis.Indian journal of ophthalmology · 2026Article
- The Clinical Significance of the Early Screening of Keratoconus and Its Impact on Maintaining Quality of Life.Life (Basel, Switzerland) · 2026Article
- Identification and Verification of Ferroptosis-Related Genes in Keratoconus Using Bioinformatics Analysis.Journal of inflammation research · 2024Article
- Article
- Awareness of Keratoconus and Its Association With Eye Rubbing Among the Population in Aseer Province.Cureus · 2023Article
- Pediatric Crosslinking: Current Protocols and Approach.Ophthalmology and therapy · 2022Review
- A hospital-based study on clinical data, demographic data and visual function of keratoconus patients in Central China.Scientific reports · 2021Article
- Increased lacrimal inflammatory mediators in patients with keratoconus.Molecular vision · 2021Article
- Interleukin-6 and tumor necrosis factor-α levels in tear film of Keratoconus patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Relevance of IgE, allergy and eye rubbing in the pathogenesis and management of Keratoconus.Indian journal of ophthalmology · 2020Review
- A Case of Early Keratoconus Associated with Eye Rubbing in a Young Child.Ophthalmology and therapy · 2020Article
- Advanced keratoconus in a child with juvenile scleroderma.Indian journal of ophthalmology · 2020Article
- A clinical study to describe the corneal topographic pattern and estimation of the prevalence of keratoconus among diagnosed cases of vernal keratoconjunctivitis.Medical journal, Armed Forces India · 2019Article
- Corneal cross-linking for keratoconus caused by compulsive eye rubbing in patients with Tourette syndrome: Three case reports.Medicine · 2019Article
- Visual and Refractive Long-Term Outcomes Following Standard Cross-Linking in Progressive Keratoconus Management.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- The correlation between keratoconus and eye rubbing: a review.International journal of ophthalmology · 2019Review
- Comment: Allergen-specific exposure associated with high immunoglobulin E and eye rubbing predisposes to progression of keratoconus.Indian journal of ophthalmology · 2017Article
- Erratum: Allergen specific exposure associated with high immunoglobulin E and eye rubbing predisposes to progression of keratoconus.Indian journal of ophthalmology · 2017Article
Corrections and comments
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- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report two male children with persistent allergic eye disease (AED) and keratoconus (KC). Both presented with symptoms of vernal keratoconjunctivitis and decreased vision. In view of unrelenting AED, serum immunoglobulin E (IgE) quantification and identification of specific allergens were advised. Increased serum IgE levels were observed in both cases. Sunflower and sheep wool were identified as specific allergens for the first and second patient respectively by skin patch test. There was complete resolution of symptoms of AED in both patients following avoidance of causative allergens. However, the progression of KC in both eyes of the first patient and one eye of the second patient was observed. They were advised collagen cross-linking. Elevated serum IgE indicates the presence of systemic allergy. Avoiding implicated allergens help alleviate ocular symptoms. Using serum IgE and identifying specific allergen can guide in the treatment of AED and thus prevent progressive KC due to eye rubbing and resulting inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.