Evidence map›Paper›PMID 28573863›Full record

ArticleMolecular pharmaceutics2017

CD38 as a PET Imaging Target in Lung Cancer.

Emily B Ehlerding, Christopher G England, Dawei Jiang, Stephen A Graves, Lei Kang, Saige Lacognata, Todd E Barnhart, Weibo Cai

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Noninvasive PET imaging of tumor PD-L1 expression withAmerican journal of nuclear medicine and molecular imaging · 2024
    Article
  5. Radionuclide-based theranostics - a promising strategy for lung cancer.European journal of nuclear medicine and molecular imaging · 2023
    Review
  6. Cannot Target What Cannot Be Seen: Molecular Imaging of Cancer Stem Cells.International journal of molecular sciences · 2023
    Review
  7. Research progress in the role of CD38 in clinical tumor treatment.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
  8. Article
  9. European journal of nuclear medicine and molecular imaging · 2022
    Article
  10. Review
  11. ImmunoPET imaging of multiple myeloma with [European journal of nuclear medicine and molecular imaging · 2021
    Article
  12. Novel Agents and Future Perspectives on Theranostics.Seminars in radiation oncology · 2021
    Review
  13. Article
  14. Article
  15. Review
  16. Radioimmunoimaging ofOncology letters · 2019
    Article
  17. Article
  18. Article
  19. Review
  20. ImmunoPET imaging of CD38 expression in hepatocellular carcinoma usingAmerican journal of translational research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Emily B EhlerdingDepartment of Medical Physics, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Christopher G EnglandDepartment of Medical Physics, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Dawei JiangDepartment of Radiology, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Stephen A GravesDepartment of Radiology, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Lei KangDepartment of Radiology, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Saige LacognataDepartment of Radiology, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Todd E BarnhartDepartment of Medical Physics, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Weibo CaiDepartment of Medical Physics, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.ORCID 0000-0003-4641-0833
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
(PQ7) Quantitative in vivo optical imaging of tumor heterogeneityR01CA205101 · NCI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI SKALA, MELISSA CAROLINE · 2016 to 2020
$1.9M
Membranous Nanogenerators for in vivo Bio-mechanical Energy HarvestingR01EB021336 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI WANG, XUDONG · 2016 to 2020
$1.7M
Novel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA169365NCI NIH HHS R01 CA205101NCI NIH HHS T32 CA009206NIBIB NIH HHS R01 EB021336NIGMS NIH HHS T32 GM008505
6 · The paper itself

Abstract

Daratumumab (Darzalex, Janssen Biotech) is a clinically approved antibody targeting CD38 for the treatment of multiple myeloma. However, CD38 is also expressed by other cancer cell types, including lung cancer, where its expression or absence may offer prognostic value. We therefore developed a PET tracer based upon daratumumab for tracking CD38 expression, utilizing murine models of non-small cell lung cancer to verify its specificity. Daratumumab was prepared for radiolabeling with

Indexed as

A549 CellsADP-ribosyl Cyclase 1AnimalsAntibodies, MonoclonalBlotting, WesternCell Line, TumorDeferoxamineFemaleFlow CytometryHumansLung NeoplasmsMiceMice, NudePositron-Emission TomographyZirconiumADP-ribosyl Cyclase 1Antibodies, MonoclonaldaratumumabDeferoxamineZirconiumCD38daratumumablung cancerpositron emission tomography (PET)zirconium-89 (89Zr)

Identifiers

PMID28573863
PMCPMC5552967
OpenAlexW2621153778

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.