Evidence map›Paper›PMID 28573829›Full record

ArticleCancer medicine2017

Comparative proteomic profiling of the serum differentiates pancreatic cancer from chronic pancreatitis.

Mayank Saraswat, Sakari Joenväärä, Hanna Seppänen, Harri Mustonen, Caj Haglund, Risto Renkonen

Abstract read
In one paragraph

Article in Cancer medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mayank SaraswatTransplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-5021-8150
Sakari JoenvääräTransplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.
Hanna SeppänenDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Harri MustonenDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Caj HaglundDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Risto RenkonenTransplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Finland ranks sixth among the countries having highest incidence rate of pancreatic cancer with mortality roughly equaling incidence. The average age of diagnosis for pancreatic cancer is 69 years in Nordic males, whereas the average age of diagnosis of chronic pancreatitis is 40-50 years, however, many cases overlap in age. By radiology, the evaluation of a pancreatic mass, that is, the differential diagnosis between chronic pancreatitis and pancreatic cancer is often difficult. Preoperative needle biopsies are difficult to obtain and are demanding to interpret. New blood based biomarkers are needed. The accuracy of the only established biomarker for pancreatic cancer, CA 19-9 is rather poor in differentiating between benign and malignant mass of the pancreas. In this study, we have performed mass spectrometry analysis (High Definition MS

Indexed as

Blood ProteinsProteomeProteomicsBiomarkers, TumorChromatography, LiquidDiagnosis, DifferentialFemaleHumansMaleMass SpectrometryModels, StatisticalPancreatic NeoplasmsPancreatitis, ChronicProtein Interaction MappingReproducibility of ResultsROC CurveBiomarkers, TumorBlood ProteinsProteomeChronic pancreatitisHDMSEOPLS-DAPancreatic adenocarcinomaPancreatic cancer

Identifiers

PMID28573829
PMCPMC5504330

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.