ArticleThe journal of physiological sciences : JPS2018
Transmural cellular heterogeneity in myocardial electromechanics.
Article in The journal of physiological sciences : JPS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Reassessment of mechanical restitution in guinea pig cardiomyocytes through refined computational modelling.Scientific reports · 2025Article
- Influence of electrolyte imbalance on regional wall motion abnormalities in STEMI patients of North Indian origin.Frontiers in cardiovascular medicine · 2023Article
- The importance of mechanical conditions in the testing of excitation abnormalities in a population of electro-mechanical models of human ventricular cardiomyocytes.Frontiers in physiology · 2023Article
- Article
- Contractile State Dependent Sarcomere Length Variability in Isolated Guinea-Pig Cardiomyocytes.Frontiers in physiology · 2022Article
- Fast-relaxing cardiomyocytes exert a dominant role in the relaxation behavior of heterogeneous myocardium.Archives of biochemistry and biophysics · 2021Article
- In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment.Progress in biophysics and molecular biology · 2021Article
- Cardiac specific transcription factor Csx/Nkx2.5 regulates transient-outward KThe journal of physiological sciences : JPS · 2020Article
- The Effects of Mechanical Preload on Transmural Differences in Mechano-Calcium-Electric Feedback in Single Cardiomyocytes: Experiments and Mathematical Models.Frontiers in physiology · 2020Article
- Effect of myocardial heterogeneity on ventricular electro-mechanical responses: a computational study.Biomedical engineering online · 2019Article
- Asparagine-linked glycosylation modifies voltage-dependent gating properties of CaThe journal of physiological sciences : JPS · 2019Article
- Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study.BioMed research international · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the differences in the action potential and contraction between the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes are essential to produce the differences in Ca
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Registered trials
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