Evidence map›Paper›PMID 28573459›Full record

ArticleMolecular neurobiology2018

Cytoskeleton-Associated Risk Modifiers Involved in Early and Rapid Progression of Sporadic Creutzfeldt-Jakob Disease.

Saima Zafar, Neelam Younas, Nadeem Sheikh, Waqas Tahir, Mohsin Shafiq, Matthias Schmitz, Isidre Ferrer, Olivier Andréoletti, Inga Zerr

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Post-translational modifications in prion diseases.Frontiers in molecular neuroscience · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Synaptotoxicity in Alzheimer's Disease Involved a Dysregulation of Actin Cytoskeleton Dynamics through Cofilin 1 Phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Saima ZafarDepartment of Neurology, Clinical Dementia Center, and DZNE, Georg-August University, University Medical Center Goettingen (UMG), Robert-Koch-Str. 40, 37075, Goettingen, Germany. sz_awaan@yahoo.com.
Neelam YounasDepartment of Neurology, Clinical Dementia Center, and DZNE, Georg-August University, University Medical Center Goettingen (UMG), Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Nadeem SheikhDepartment of Zoology, University of the Punjab, Lahore, Pakistan.
Waqas TahirDepartment of Neurology, Clinical Dementia Center, and DZNE, Georg-August University, University Medical Center Goettingen (UMG), Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Mohsin ShafiqDepartment of Neurology, Clinical Dementia Center, and DZNE, Georg-August University, University Medical Center Goettingen (UMG), Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Matthias SchmitzDepartment of Neurology, Clinical Dementia Center, and DZNE, Georg-August University, University Medical Center Goettingen (UMG), Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Isidre FerrerInstitute of Neuropathology, IDIBELL-University Hospital Bellvitge, University of Barcelona, Hospitalet de Llobregat, Spain.
Olivier AndréolettiInstitut National de la Recherche Agronomique/Ecole Nationale Vétérinaire, Toulouse, France.
Inga ZerrDepartment of Neurology, Clinical Dementia Center, and DZNE, Georg-August University, University Medical Center Goettingen (UMG), Robert-Koch-Str. 40, 37075, Goettingen, Germany.
University of Göttingen · DEUniversitätsmedizin Göttingen · DEBellvitge University Hospital · ESÉcole Nationale Vétérinaire de Toulouse · FRGerman Center for Neurodegenerative Diseases · DEUniversity of the Punjab · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A high priority in the prion field is to identify pre-symptomatic events and associated profile of molecular changes. In this study, we demonstrate the pre-symptomatic dysregulation of cytoskeleton assembly and its associated cofilin-1 pathway in strain and brain region-specific manners in MM1 and VV2 subtype-specific Creutzfeldt-Jakob disease at clinical and pre-clinical stage. At physiological level, PrP

Indexed as

Disease ProgressionActinsAgedAmyloid beta-PeptidesAnimalsCalcineurinCalcium-Binding ProteinsCells, CulturedCell SurvivalCofilin 1Creutzfeldt-Jakob SyndromeCytoskeletonFemaleGene SilencingHumansLim KinasesActinsAif1 protein, mouseAmyloid beta-PeptidesCalcineurinCalcium-Binding ProteinsCofilin 1LIMK1 protein, humanLim KinasesMicrofilament ProteinsPhosphoprotein PhosphatasesPrPC Proteinsrho-Associated KinasesRNA, Small InterferingROCK2 protein, humanSSH1 protein, humanActinAPPCerebellumCJDCofilinCortexLIMKMicrogliaMM1Prion proteinRockSSH1VV2

Identifiers

PMID28573459
OpenAlexW2621242441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.