ArticleEuropean journal of nutrition2018
Oxidative damage of mitochondrial respiratory chain in different organs of a rat model of diet-induced obesity.
Article in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Pancreatic β-cell mitophagy as an adaptive response to metabolic stress and the underlying mechanism that involves lysosomal CaExperimental & molecular medicine · 2023Review
- Lysosomal CaNature communications · 2022Article
- Article
- Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants.Biomolecules · 2020Review
- Oxidative stress, nutritional antioxidants and beyond.Science China. Life sciences · 2020Review
- A model of mitochondrial OAmerican journal of physiology. Renal physiology · 2020Article
- Effects of AT1 receptor antagonism on interstitial and ultrastructural remodeling of heart in response to a hypercaloric diet.Physiological reports · 2019Article
- Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1.Frontiers in endocrinology · 2019Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeMitochondrial dysfunction plays an important role in the development of obesity and obesity-associated metabolic diseases.
methodsIn this study, we dynamically observed the characteristics of mitochondrial damage in a rat model of diet-induced obesity (DIO). From the 2nd to the 10th week, animals were killed every 2 weeks and the heart, liver, kidney, and testicular tissues were harvested. Mitochondria were isolated and the activities of respiratory chain complexes I, II, III, and IV as well as the 8-Hydroxy-2-deoxy Guanosine content were determined. Reactive oxygen species and malondialdehyde were measured.
resultsMitochondrial damages were observed in the heart and liver of DIO and DR rats, and the damages occurred later in DR group than that in DIO group. The mitochondrial membrane potential of heart and liver decreased in DIO and DR groups. The activity of the heart mitochondria complexes I, III, and IV (composing NADH oxidative respiratory) was higher in the early stage of DIO and lower in the end of week 10. The higher activity of the liver complexes I, III, and IV was found until the end of week 10 in DIO and DR groups, accompanied with enhanced oxidative stress. Besides, mitochondrial DNA damages were observed in all tissues.
conclusionIn DIO rats, the heart mitochondrial dysfunction occurred first and the liver presented the strongest compensatory ability against oxidative stress.
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