Evidence map›Paper›PMID 28573337›Full record

ArticleGlycoconjugate journal2017

Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells.

Silvia Fallarini, Alvaro Brittoli, Michele Fiore, Grazia Lombardi, Olivier Renaudet, Barbara Richichi, Cristina Nativi

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In one paragraph

Article in Glycoconjugate journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Silvia FallariniDepartment of Pharmaceutical Sciences, University of Piemonte Orientale "Amedeo Avogadro", Largo Donegani 2, 28100, Novara, Italy.
Alvaro BrittoliDepartment of Pharmaceutical Sciences, University of Piemonte Orientale "Amedeo Avogadro", Largo Donegani 2, 28100, Novara, Italy.
Michele FioreUniversité de Lyon, Claude Bernard Lyon 1, 43 bvd du 11 Novembre 1918, 69622, Villeurbanne Cedex, France.
Grazia LombardiDepartment of Pharmaceutical Sciences, University of Piemonte Orientale "Amedeo Avogadro", Largo Donegani 2, 28100, Novara, Italy.
Olivier RenaudetCNRS, DCM, Université Grenoble-Alpes, 38000, Grenoble, France.
Barbara RichichiDepartment of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, 50019, Sesto Fiorentino, FI, Italy. barbara.richichi@unifi.it.
Cristina NativiDepartment of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, 50019, Sesto Fiorentino, FI, Italy.
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Florence · ITCentre National de la Recherche Scientifique · FRUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of a rigid α-Tn mimetic (compound 1) to activate murine invariant natural killer T (iNKT) and human natural killer (NK) cells, two subsets of lymphocytes involved in cancer immunesurveillance, was investigated. For this purpose, the mimetic 1 was properly conjugated to a stearic acid containing glycerol-based phospholipid (compound 5) to be presented, in the context of the conserved non polymorphic major histocompatibility complex class I-like molecules (CD1d), to iNKT cells. On the contrary, the mimetic 1 was conjugated to a multivalent peptide-based scaffold (compound 6) to induce NK cell activation.

Indexed as

AnimalsAntigens, Tumor-Associated, CarbohydrateBiological AssayCell DegranulationCell SurvivalGlycolipidsGlycopeptidesHumansHybridomasInterleukin-2K562 CellsKiller Cells, NaturalLymphocyte ActivationMiceMolecular MimicryNatural Killer T-CellsAntigens, Tumor-Associated, CarbohydrateGlycolipidsGlycopeptidesInterleukin-2Tn antigenGlycomimeticImmunotherapyInvariant natural killer T cellsNatural killer cellsα-Tn antigen

Identifiers

PMID28573337
OpenAlexW2621334387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.