Evidence map›Paper›PMID 28573151›Full record

ArticleNeurogenesis (Austin, Tex.)2017

Nervous system development relies on endosomal trafficking.

Ivan Mestres, Ching-Hwa Sung

Abstract read
In one paragraph

Article in Neurogenesis (Austin, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Late Endosome Transport by RILP-RAB7A Promotes Dendrite Arborization Independently of Degradation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Late endosome transport by RILP-RAB7A promotes dendrite arborization.bioRxiv : the preprint server for biology · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ivan MestresDFG-Research Center for Regenerative Therapies, Cluster of Excellence, TU Dresden, Dresden, Germany.
Ching-Hwa SungDepartment of Ophthalmology, Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY, USA.

Funding

MOLECULAR BASIS OF PROTEIN TRANSPORT IN PHOTORECEPTORSR01EY011307 · NEI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SUNG, CHING-HWA · 1996 to 2015
$7.2M
Structural and functional integrity and microenvironment of RPE cellsR01EY016805 · NEI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SUNG, CHING-HWA · 2006 to 2015
$3.5M
NEI NIH HHS R01 EY011307NEI NIH HHS R01 EY016805
6 · The paper itself

Abstract

Accumulating findings have begun to unveil the important role of the endosomal machinery in the nervous system development. Endosomes have been linked to the differential segregation of cell fate determining molecules in asymmetrically dividing progenitors during neurogenesis. Additionally, the precise removal and reinsertion of membrane components through endocytic trafficking regulates the spatial and temporal distribution of signaling receptors and adhesion molecules, which determine the morphology and motility of migrating neurons. Emerging evidence suggests that the role of the endosomal sorting adaptors is dependent upon cell type and developmental stage. The repertoire of the signaling receptors and/or adhesion molecules sorted by the endosome during these processes remains to be explored. In this commentary, we will briefly address the progress in this research field.

Indexed as

asymmetric mitosisbrain developmentendosomal systemmembrane traffickingneuron migrationsmad anchor for receptor activation (SARA)

Identifiers

PMID28573151
PMCPMC5443187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.