ArticleWorld journal of gastrointestinal pathophysiology2017
Rectification of oxygen transfer through the rat colonic epithelium.
Article in World journal of gastrointestinal pathophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Regional Heterogeneity in Intestinal Epithelial Barrier Permeability and Mesenteric Perfusion After Thoracic Spinal Cord Injury.Digestive diseases and sciences · 2024Article
- Hypoxia attenuate ionic transport in the isolated gill epithelium of Carcinus maenas.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
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Authors and funding
4 authors.
Funding
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Abstract
aimTo assess whether higher sensitivity of colonic epithelium to hypoxia at the serosal side is associated with oxygen transfer asymmetry.
methodsRats were fed either with normal chow or a low-sodium diet. Tissues were mounted as flat sheets in a modified, airtight Ussing chamber with oxygen meters in each hemichamber. Mucosal samples from normal diet animals were studied under control conditions, in low-chloride solution and after adding chloride secretion inhibitors and chloride secretagogues. Samples from sodium-deprived rats were studied before and after ouabain addition. In separate experiments, the correlation between short-circuit current and oxygen consumption was analyzed. Finally, hypoxia was induced in one hemichamber to assess the relationship between its oxygen content and the oxygen pressure difference between both hemichambers.
resultsIn all studied conditions, oxygen consumption was larger in the serosal hemichamber than in the mucosal one (
conclusionSerosal oxygen supply is more readily available to support short-circuit current. This may be partly due to a rectifying behavior of transepithelial oxygen transfer.
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