ArticleEvidence-based complementary and alternative medicine : eCAM2017
Investigating Potential Modes of Actions of
Article in Evidence-based complementary and alternative medicine : eCAM, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Evaluation of the Potential Hypoglycaemic Properties ofPlants (Basel, Switzerland) · 2024Article
- Ethnobotanical study of wild edible plants in Arsi Robe district of East Arsi Zone, Ethiopia.Journal of ethnobiology and ethnomedicine · 2024Article
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- Article
- Antidiarrheal and Antibacterial Activities ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Evaluation of in vivo Antidiabetic, Antidyslipidemic and in vitro Anti-Oxidant Activity of Extract and Solvent Fractions ofJournal of experimental pharmacology · 2022Article
- Evaluation of Antidiabetic and Antioxidant Activity of Leaf Extract and Solvent Fractions ofJournal of experimental pharmacology · 2021Article
- Evaluation ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Evaluation ofBioMed research international · 2021Article
- Methanolic Crude Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Evaluation of Antidiarrheal Activity of 80% Methanolic Extract of the Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Hypoglycemic, Anti-Hyperglycemic and Anti-Hyperlipidemic Effects ofJournal of experimental pharmacology · 2020Article
- Evaluation of in vitro and in vivo Anti-Diabetic, Anti-Hyperlipidemic and Anti-Oxidant Activity of Flower Crude Extract and Solvent Fractions ofJournal of experimental pharmacology · 2020Article
- Evaluation of the Antispasmodic and Antisecretory Activities of the 80% Methanol Extracts ofJournal of evidence-based integrative medicineArticle
- Evaluation of In Vivo Antidiabetic, In Vitro α-Amylase Inhibitory, and In Vitro Antioxidant Activity of Leaves Crude Extract and Solvent Fractions ofJournal of evidence-based integrative medicineArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFruits of
methodsFractions of chloroform, n-butanol, and water were obtained from 80% methanol extract, which was prepared by maceration. Antidiarrheal activities and the modes of actions were investigated in mice.
resultsIn castor oil induced diarrheal model, the extract delayed onset of diarrhea and reduced number and weight of feces at all tested doses significantly. In this model all fractions significantly delayed onset of diarrhea at all tested doses. Charcoal meal test showed that the extract and all the fractions produced a significant antimotility effect at all tested doses. Enteropooling test showed that the extract as well as n-butanol and aqueous fractions at all tested doses produced a significant decline in volume and weight of intestinal contents, whereas chloroform fraction had substantial effect only at high dose.
conclusionThis study demonstrated that the extract and solvent fractions produced antidiarrheal activities due to dual inhibitory effect, intestinal motility, and fluid secretion, with the aqueous fraction being the most active among fractions in three models.
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Registered trials
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