Evidence map›Paper›PMID 28572790›Full record

ArticleFrontiers in neurology2017

Photolysis of Caged-GABA Rapidly Terminates Seizures

Dan Wang, Zhixin Yu, Jiaqing Yan, Fenqin Xue, Guoping Ren, Chenxi Jiang, Weimin Wang, Yueshan Piao, Xiaofeng Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Dan WangNeuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China.
Zhixin YuNeuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jiaqing YanCollege of Electrical and Control Engineering, North China University of Technology, Beijing, China.
Fenqin XueCore Facilities Center, Capital Medical University, Beijing, China.
Guoping RenNeuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chenxi JiangNeuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China.
Weimin WangDepartment of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yueshan PiaoDepartment of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xiaofeng YangNeuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNChinese Institute for Brain Research · CNNorth China University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The therapy of focal epilepsy remains unsatisfactory for as many as 25% of patients. The photolysis of caged-γ-aminobutyric acid (caged-GABA) represents a novel and alternative option for the treatment of intractable epilepsy. Our previous experimental results have demonstrated that the use of blue light produced by light-emitting diode to uncage ruthenium-bipyridine-triphenylphosphine-c-GABA (RuBi-GABA) can rapidly terminate paroxysmal seizure activity both

Indexed as

4-aminopyridinefocal neocortical epilepsyphotolysisRuBi-GABAseizure

Identifiers

PMID28572790
PMCPMC5435768
OpenAlexW2615180884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.