Evidence map›Paper›PMID 28572711›Full record

ArticleMediators of inflammation2017

Buprenorphine Alters Inflammatory and Oxidative Stress Molecular Markers in Arthritis.

Mahadevappa Hemshekhar, Vidyanand Anaparti, Carol Hitchon, Neeloffer Mookherjee

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mahadevappa HemshekharManitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-5016-501X
Vidyanand AnapartiManitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-9290-8555
Carol HitchonDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
Neeloffer MookherjeeManitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-9350-4157
University of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Buprenorphine is recommended for use as an analgesic in animal models including in murine models of collagen-induced arthritis (CIA). However, the effect of buprenorphine on the expression of disease-associated biomarkers is not well defined. We examined the effect of buprenorphine administration on disease progression and the expression of inflammatory and oxidative stress markers, in a murine model of CIA. Buprenorphine administration altered the expression of cytokines, IFN-

Indexed as

Oxidative StressAdultAgedAnalgesics, OpioidAnimalsAntioxidantsArthritis, ExperimentalArthritis, RheumatoidBiomarkersBuprenorphineCatalaseCohort StudiesCollagenCytokinesDisease Models, AnimalDisease ProgressionAnalgesics, OpioidAntioxidantsBiomarkersBuprenorphineCatalaseCollagenCytokinesMatrix Metalloproteinase 3MMP3 protein, humanNitric Oxide Synthase Type IINOS2 protein, humanNos2 protein, mouseSOD1 protein, humanSod1 protein, mouseSuperoxide Dismutase-1

Identifiers

PMID28572711
PMCPMC5441125
OpenAlexW2612630426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.